Nickel-Catalyzed Asymmetric Cross-Electrophile Coupling Reactions

The merger of cross-electrophile coupling and asymmetric catalysis provides a novel approach to the preparation of optically active compounds. This method is often endowed with high step economy, mild conditions, and excellent tolerance of functional groups. Recent advances in the research field of nickel-catalyzed asymmetric cross-electrophile coupling reactions are highlighted in this concise Synpacts article. Introduction Asymmetric Cross-Electrophile Coupling Reactions between Organohalides Asymmetric Electrophilic Ring-Opening Reactions Asymmetric Electrophilic Difunctionalization of Alkenes Two-Component Electrophilic Difunctionalization of Alkenes Involving Arylnickelation as an Enantiodetermining Step Two-Component Electrophilic Difunctionalization of Alkenes Involving Carbamoylnickelation as an Enantiodetermining Step Three-Component Electrophilic Difunctionalization of Alkenes Asymmetric Electrophilic Functionalization of Carbonyl Compounds Summary