期刊
SURGERY TODAY
卷 51, 期 4, 页码 526-536出版社
SPRINGER
DOI: 10.1007/s00595-020-02105-4
关键词
Prior bilioenteric anastomosis; Liver resection; Hepatectomy; Bile leakage; Surgical site infection
类别
Hepatectomy with prior bilioenteric anastomosis is associated with higher rates of major complications, surgical site infections, organ/space infections, and bile leakage compared to those without prior anastomosis. Bile leakage is a significant risk factor for organ/space infections in patients with prior anastomosis, highlighting the importance of meticulous liver transection to reduce bile leakage and prevent infectious complications.
Purpose The aims of this study were to compare the perioperative outcomes after hepatectomy with prior bilioenteric anastomosis to those without prior anastomosis, and to elucidate the mechanisms and preventative measures of its characteristic complications. Methods The demographic data and perioperative outcomes of 525 hepatectomies performed between January 2007 and December 2018, including 40 hepatectomies with prior bilioenteric anastomosis, were retrospectively analyzed. Results A propensity score matching analysis demonstrated that hepatectomies with prior bilioenteric anastomosis were associated with a higher frequency of major complications (p = 0.015), surgical site infection (p = 0.005), organ/space surgical site infection (p = 0.003), and bile leakage (p = 0.007) compared to those without. A multivariate analysis also elucidated that prior bilioenteric anastomosis was one of the independent risk factors of organ/space surgical site infection. In the patients with prior bilioenteric anastomosis, bile leakage was associated with organ/space surgical site infection at a significantly higher rate than those without prior bilioenteric anastomosis (p < 0.001). Conclusions Prior bilioenteric anastomosis is a strong risk factor for organ/space surgical site infections, which might be induced by bile leakage. To prevent infectious complications after hepatectomy with prior bilioenteric anastomosis, meticulous liver transection to reduce bile leakage rate is thus considered to be mandatory.
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