期刊
CLINICAL REHABILITATION
卷 31, 期 1, 页码 71-81出版社
SAGE PUBLICATIONS LTD
DOI: 10.1177/0269215515626232
关键词
Depression; stroke; rehabilitation; antidepressive agents; psychotherapy
资金
- Natural Science Foundation of China [81100243, 81171131, 81272564, 81272795, 81100893, 81172197, 81372484]
- Natural Science Foundation of Liaoning Province in China [L2013296]
- Liaoning Science and Technology Plan Projects [2011225020]
Objective: To determine the appropriate treatments for post-ischaemic stroke depression at different times after stroke. Design: A single-blind, randomized, controlled trial that compared three intervention groups, with subgroups stratified by time after stroke. Setting: Outpatient clinic. Subjects: Eligible patients were recruited at discharge (n = 73) and three (n = 67), six (n = 65), and nine months (n = 69) after discharge, and patients completed mood questionnaires. Interventions: Patients were randomly distributed into three groups: Group A received placebos and participated in general discussions; Group B, received citalopram and participated in general discussions; and Group C, received placebos and underwent cognitive behavioural therapy. All three groups participated in rehabilitation during three months of follow-up. Main measures: Outcome was assessed three months after baseline using the 17-item Hamilton Depression Scale (HAMD(17)) and the Bech-Rafaelsen Melancholia Scale (MES). During treatment, the Udvalg for Kliniske Undersogelser side-effect scale was also administered. Results: When stratification was not considered, the scores of Group B on the Melancholia Scale were lower than those of Group A (P = 0.02); when the four time-based subgroups were analysed, significant differences were observed between Groups A and B (P-MES = 0.02, P-HAMD17 = 0.02) in the group recruited six months after discharge and between Groups A and C (P-MES = 0.01) in the last time period nine months after discharge. Conclusions: The effects of citalopram or cognitive behavioural therapy is similar to the effect of rehabilitation alone for early-onset post-ischaemic depression; rehabilitation and citalopram for delayed-onset post-ischaemic depression; and rehabilitation and cognitive behavioural therapy for late-onset postischaemic depression are more effective than rehabilitation alone.
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