期刊
SUBSTANCE USE & MISUSE
卷 55, 期 11, 页码 1900-1901出版社
TAYLOR & FRANCIS INC
DOI: 10.1080/10826084.2020.1791184
关键词
Opioid Use Disorder; OUD; COVID; coronavirus; risk factors
资金
- NIDA NIH HHS [R01 DA048009] Funding Source: Medline
Background Alarms have been raised that COVID-19 may disproportionately affect certain populations with substance use disorders, particularly Opioid Use Disorder (OUD), however warnings have largely focused on social risks such as reduced availability of services.Objectives:This commentary highlights three plausible biological mechanisms for potentially worsened outcomes in patients with OUD who contract COVID-19.Results:Opioid-related respiratory depression may amplify risks of hypoxemia from COVID-19 viral pneumonia. Complex opioid immune modulation may impact host response to COVID-19, though the effect direction and clinical significance are unclear. Drug-drug interactions may affect individuals with OUD who are co-administered medications for OUD and medications for COVID-19, particularly due to cardiac adverse effects.Conclusions/Importance:There are plausible biological mechanisms for potentially worsened outcomes in patients with OUD who contract COVID-19; these mechanisms require further study, and should be considered in individuals with OUD.
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