期刊
STRAHLENTHERAPIE UND ONKOLOGIE
卷 196, 期 11, 页码 1018-1033出版社
SPRINGER HEIDELBERG
DOI: 10.1007/s00066-020-01637-5
关键词
Ionizing radiation; Biomarkers of radiation exposure; Prostate cancer; Systemic immune modulation; Immunophenotyping
资金
- European Union's Seventh Framework Programme from the OPERRA project (Euratom/FP7) [604984 604984]
- European Social Fund [POWR.03.02.00-00-I029]
- National Science Centre, Poland NCN BiTIMS [2015/19/B/ST6/01736]
- German Federal Ministry of Education and Research (BMBF
- GREWIS-alpha) [02NUK050E]
Background In this exploratory study, the impact of local irradiation on systemic changes in stress and immune parameters was investigated in eight patients treated with intensity-modulated radiation therapy (IMRT) or stereotactic ablative body radiotherapy (SABR) for prostate adenocarcinoma to gain deeper insights into how radiotherapy (RT) modulates the immune system. Patients and methods RT-qPCR, flow cytometry, metabolomics, and antibody arrays were used to monitor a panel of stress- and immune-related parameters before RT, after the first fraction (SABR) or the first week of treatment (IMRT), after the last fraction, and 3 weeks later in the blood of IMRT (N & x202f;= 4) or SABR (N & x202f;= 4) patients. Effect size analysis was used for comparison of results at different timepoints. Results Several parameters were found to be differentially modulated in IMRT and SABR patients: the expression ofTGFB1,IL1B, andCCL3genes; the expression of HLA-DR on circulating monocytes; the abundance and ratio of phosphatidylcholine and lysophosphatidylcholine metabolites in plasma. More immune modulators in plasma were modulated during IMRT than SABR, with only two common proteins, namely GDF-15 and Tim-3. Conclusion Locally delivered RT induces systemic modulation of the immune system in prostate adenocarcinoma patients. IMRT and SABR appear to specifically affect distinct immune components.
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