期刊
SMALL
卷 16, 期 39, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202002515
关键词
artificial skin; drug development; microfluidics; organ-on-a-chip; skin-on-a-chip
类别
资金
- Australian Research Council [DE170100239, DP200101248, DP180102049]
- Australian National Health and Medical Research Council (NHMRC) [CRE APP1135076]
- Australian Research Council [DP200101248, DE170100239] Funding Source: Australian Research Council
The role of skin in the human body is indispensable, serving as a barrier, moderating homeostatic balance, and representing a pronounced endpoint for cosmetics and pharmaceuticals. Despite the extensive achievements of in vitro skin models, they do not recapitulate the complexity of human skin; thus, there remains a dependence on animal models during preclinical drug trials, resulting in expensive drug development with high failure rates. By imparting a fine control over the microenvironment and inducing relevant mechanical cues, skin-on-a-chip (SoC) models have circumvented the limitations of conventional cell studies. Enhanced barrier properties, vascularization, and improved phenotypic differentiation have been achieved by SoC models; however, the successful inclusion of appendages such as hair follicles and sweat glands and pigmentation relevance have yet to be realized. The present Review collates the progress of SoC platforms with a focus on their fabrication and the incorporation of mechanical cues, sensors, and blood vessels.
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