期刊
SMALL
卷 16, 期 28, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202001223
关键词
atomic layer deposition; miRNA-155; photoelectrochemical biosensors; photoresponsive nanochannels
类别
资金
- National Natural Science Foundation of China [51822501]
- Natural Science Funds for Distinguished Young Scholar of Jiangsu Province [BK20170023]
- Fundamental Research Funds for the Central Universities [3202006301, 3202006403]
- Qing Lan Project of Jiangsu Province
- International Foundation for Science, Stockholm, Sweden
- Organization for the Prohibition of Chemical Weapons, The Hague, Netherlands [F/4736-2]
- Top 6 High-Level Talents Program of Jiangsu Province [2017-GDZB-006]
- Natural Science Foundation of Jiangsu Province [BK20181274]
- Tribology Science Fund of State Key Laboratory of Tribology [SKLTKF15A11]
- Open Research Fund of State Key Laboratory of High Performance Complex Manufacturing, Central South University [Kfkt2016-11]
- Open Research Fund of State Key Laboratory of Fire Science [HZ2017-KF05]
- Open Research Fund of State Key Laboratory of solid lubrication [LSL-1607]
Artificial photoresponsive nanochannels have attracted widespread attention because of their capacity to achieve ion transport through light modulation. Herein, a biosensor for ultrasensitive miRNA-155 detection is devised based on molybdenum disulfide (MoS2) modified porous anodic aluminum oxide (AAO) photoresponsive nanochannels by atomic layer deposition (ALD). According to the optimized experimental results, when the cycles of ALD, the wavelength, and the power of the excitation laser are 70 cycles, 450 nm, and 80 mW, respectively, the most supreme photocurrent performance of these photoresponsive nanochannels are obtained. AAO nanochannels modified with MoS(2)can work as a photoelectrochemical (PEC) biosensor by generating photoexcitation current; what is more, the high channel density in AAO can magnify the ion current signal response effectively by aggrandizing the flux of electroactive species. By using AAO photoresponsive nanochannels with an average diameter of 150 nm as PEC biosensor, an ultrasensitive detection record ranging from 0.01 fM to 0.01 nM with a detection limit of 3 aM can be achieved. This work not only proposes a simple method for manufacturing semiconductor photoresponsive nanochannels, but also exhibits great potential in the ultrasensitive detection of biomolecules.
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