期刊
SMALL
卷 16, 期 28, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202000589
关键词
hypoxia relief; immunological memory; manganese dioxide; photodynamic therapy; skin abscesses
类别
资金
- National Basic Research Programs of China [2016YFA0201200]
- National Key Research and Development (RAMP
- D) Program of China [2017YFE0131700]
- Natural Science Foundation of Jiangsu Higher Education Institutions of China [19KJA310008]
- National Natural Science Foundation of China [51525203, 51761145041, 81602181]
- Collaborative Innovation Center of Suzhou Nano Science and Technology
- 111 program from the Ministry of Education of China
The emergence of drug-resistant bacteria and easy recurrence has been challenging in the clinical treatment of skin abscesses resulting from bacterial infections (e.g., byStaphylococcus aureus(S. aureus)). Herein, an antibacterial nanoagent capable of modulating the abscess microenvironment is designed to enhance photodynamic treatment of skin abscesses, and subsequently activate the immune system to effectively prevent abscess recurrence. In the system, manganese dioxide nanoparticles (MnO(2)NPs) with high catalytic reactivity toward H(2)O(2)are modified with photosensitizer chlorine e6 (Ce6) and coated with polyethylene glycol (PEG). The obtained Ce6@MnO2-PEG NPs, by triggering the decomposition of lesion endogenous H2O2, are able to effectively relieve the hypoxic abscess microenvironment duringS. aureusinfection. The light-triggered photodynamic bacterial killing effect could thus be remarkably enhanced, resulting in effective in vivo therapy ofS. aureus-induced skin abscesses. Interestingly, a notable pathogen-specific immunological memory effect against future infection by the same species of bacteria is elicited after such treatment, owing to the release of bacterial antigens post photodynamic therapy (PDT) together with the adjuvant-like function of manganese ions to activate the host immune system. This work thus presents a new type of photodynamic nanoagent particularly promising for highly effective light-triggered abscess treatment and prevention of abscess recurrence.
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