期刊
SMALL
卷 16, 期 26, 页码 -出版社
WILEY-V C H VERLAG GMBH
DOI: 10.1002/smll.202000239
关键词
human IgG detection; label-free biosensors; microdisk lasers; optofluidics
类别
资金
- Special Project of National Key Technology R&D Program of the Ministry of Science and Technology of China [2016YFC0201401]
- National Natural Science Foundation of China [61922040]
- Shanghai Science and Technology Committee [18JC1411500]
- National Key Basic Research Program of China (Program 973) [2015CB352006]
Whispering gallery mode (WGM) microresonators have been used as optical sensors in fundamental research and practical applications. The majority of WGM sensors are passive resonators that require complex systems, thereby limiting their practicality. Active resonators enable the remote excitation and collection of WGM-modulated fluorescence spectra, without requiring complex systems, and can be used as alternatives to passive microresonators. This paper demonstrates an active microresonator, which is a microdisk laser in a hyperboloid-drum (HD) shape. The HD microdisk lasers are a combination of a rhodamine B-doped photoresist and a silica microdisk. These HD microdisk lasers can be utilized for the detection of label-free biomolecules. The biomolecule concentration can be as low as 1 ag mL(-1), whereas the theoretical detection limit of the biosensor for human IgG in phosphate buffer saline is 9 ag mL(-1) (0.06 a(M)). Additionally, the biosensors are able to detect biomolecules in an artificial serum, with a theoretical detection limit of 9 ag mL(-1) (0.06 a(M)). These results are approximately four orders of magnitude more sensitive than those for the typical active WGM biosensors. The proposed HD microdisk laser biosensors show enormous detection potential for biomarkers in protein secretions or body fluids.
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