期刊
SENSORS AND ACTUATORS B-CHEMICAL
卷 312, 期 -, 页码 -出版社
ELSEVIER SCIENCE SA
DOI: 10.1016/j.snb.2020.127962
关键词
Flexible biosensor; Mediator-free direct electron transfer; Sweat glucose monitoring; Surface electromyography monitoring
资金
- Shenzhen Science and Technology Innovation Committee [JCYJ20180307155036127]
- National Natural Science Foundation of China [21775168, 11474364, 51573213, 51905557, 51290271]
- National Key R&D Program of China [2017YFE0102400]
- Department of Science and Technology of Guangdong Province [2017A020211004]
- Australia-China Joint Institute for Health Technology and Innovation
Wearable electrochemical biosensors, which measure the concentration of small biochemical molecules in biofluids in a non-invasive way, are still highly desired. Herein, a wearable, mediator-free electrochemical biosensor for real-time sweat glucose monitoring is proposed. A flexible and hierarchical meso/macro porous carbon nanotubes (CNT) - ethylene-vinyl acetate copolymer (EVA) film is constructed as the sensing substrate in a facile route. Thanks to its well-formed three-dimensional conducive nanoporous structure, direct electron transfer-type of bioelectrocatalysis is successfully realized on the glucose oxidase-horseradish peroxidase bienzyme functionalized CNT-EVA film for glucose monitoring without any mediator. The as-fabricated biosensors show excellent selectivity to glucose with a super-high sensitivity of 270 +/- 10 mu A mM(-1)cm(-2). This flexible CNT-EVA films also are utilized for monitoring the surface electromyography (sEMG) with high signal-tobackground sensitivity due to its high electrical conductivity as well as good conformability to the skin. On-body experiments illustrated the capability of the proposed flexible biosensor for monitoring sweat glucose and surface electromyography simultaneously, guiding the way for measuring multiplex physiological signals for health monitoring, early diagnosis, and clinical research in future.
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