期刊
SENSORS
卷 20, 期 15, 页码 -出版社
MDPI
DOI: 10.3390/s20154118
关键词
three-dimensional microfluidic devices; spraying; colorimetric analysis; nitrite; thiocyanate
资金
- Natural Science Foundation of Hunan Province [2018JJ3500]
- National Natural Science Foundation of China [21804114]
- College Students Platform for Innovation and Entrepreneurship Training Program of Hunan province [S201910530018]
The concentrations of nitrite and thiocyanate in saliva can be used as the biomarkers of the progression of periodontitis disease and environmental tobacco smoke exposure, respectively. Therefore, it is particularly necessary to detect these two indicators in saliva. Herein, the three-dimensional single-layered paper-based microfluidic analytical devices (3D sl-mu PADs) were, for the first time, fabricated by the spraying technique for the colorimetric detection of nitrite and thiocyanate at the same time. The conditions for 3D sl-mu PADs fabrication were optimized in order to well control the penetration depth of the lacquer in a paper substrate. Then, the developed 3D sl-mu PADs were utilized to simultaneously detect nitrite and thiocyanate and the limits of detection are 0.0096 and 0.074 mM, respectively. What is more, the mu PADs exhibited good specificity, good repeatability, and acceptable recoveries in artificial saliva. Therefore, the developed 3D sl-mu PADs show a great potential to determine nitrite and thiocyanate for the assessment of the human health.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据