期刊
SENSORS
卷 20, 期 13, 页码 -出版社
MDPI
DOI: 10.3390/s20133678
关键词
surface plasmon resonance; biosensors; bio-functionalization optimization; cost-effective biosensors; lab-on-a-chip
资金
- H2020-Electronic Smart Systems-SiMBiT: Single molecule bio-electronic smart system array for clinical testing [824946]
- Italian MIUR PON project PMGB -Sviluppo di piattaforme meccatroniche, genomiche e bioinformatiche per l'oncologia di precisione [ARS01_01195]
- CSGI
The continuous improvement of the technical potential of bioelectronic devices for biosensing applications will provide clinicians with a reliable tool for biomarker quantification down to the single molecule. Eventually, physicians will be able to identify the very moment at which the illness state begins, with a terrific impact on the quality of life along with a reduction of health care expenses. However, in clinical practice, to gather enough information to formulate a diagnosis, multiple biomarkers are normally quantified from the same biological sample simultaneously. Therefore, it is critically important to translate lab-based bioelectronic devices based on electrolyte gated thin-film transistor technology into a cost-effective portable multiplexing array prototype. In this perspective, the assessment of cost-effective manufacturability represents a crucial step, with specific regard to the optimization of the bio-functionalization protocol of the transistor gate module. Hence, we have assessed, using surface plasmon resonance technique, a sustainable and reliable cost-effective process to successfully bio-functionalize a gold surface, suitable as gate electrode for wide-field bioelectronic sensors. The bio-functionalization process herein investigated allows to reduce the biorecognition element concentration to one-tenth, drastically impacting the manufacturing costs while retaining high analytical performance.
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