期刊
SEMINARS IN LIVER DISEASE
卷 40, 期 3, 页码 298-306出版社
THIEME MEDICAL PUBL INC
DOI: 10.1055/s-0040-1708540
关键词
NLRP3; nonalcoholic steatohepatitis; alcoholic steatohepatitis; inflammation; inflammasome
资金
- NIH [R01 DK113592, U01 AA024206]
- German Research Foundation [WR173/3-1, SFB/TRR57]
- German Cancer Aid (Deutsche Krebshilfe) [70113000]
Nonalcoholic steatohepatitis (NASH) and alcoholic hepatitis (ASH) are advanced forms of fatty liver diseases that are associated with a high morbidity and mortality worldwide. Patients with ASH or NASH are more susceptible to the progression of fibrosis and cirrhosis up to the development of hepatocellular carcinoma. Currently, there are limited medical therapies available. Accompanied by the asymptomatic disease progression, the demand for liver transplants is high. This review provides an overview about the growing evidence for a central role of NLR family pyrin domain containing 3 (NLRP3) inflammasome, a multiprotein complex that acts as a central driver of inflammation via activation of caspase 1, maturation and release of pro-inflammatory cytokines including interleukin-1 beta, and trigger of inflammatory pyroptotic cell death in both NASH and ASH. We also discuss potential therapeutic approaches targeting NLRP3 inflammasome and related upstream and downstream pathways to develop prognostic biomarkers and medical treatments for both liver diseases.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据