期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 726, 期 -, 页码 -出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2020.138516
关键词
ARGs; Proliferation; New quantitative parameter; Sulfonamides; QSAR
资金
- National Natural Science Foundation of China [31760165, 41461094, 41661095]
- Outstanding Scholarship of Jiangxi Scientific Committee [20192BCBL23014]
- Natural Science Foundation of Jiangxi Province [20181BAB203023]
- Education Department of Jiangxi Province [GJJ160727, GJJ190569]
Antibiotic resistance genes (ARGs) have been widely detected around the world and are generally viewed as emerging pollutants with environmental persistence. The proliferation of ARGs can be easily promoted by antibiotics. However, the dynamics of ARGs in the environment are still unable to be quantified using a single parameter, which is vital to evaluating the ability of ARGs to spread by antibiotics and effectively controlling ARGs. A new parameter, termed the relative area ratio of sample to control (Delta A(R)), was developed based on the quantitative features determined by ARG-time curves in soils contaminated with sulfonamides (SAs) and verified by quantitative structure-activity relationships (QSARs) models. The results showed that Delta A(R) can not only be used to accurately quantify the characteristics of SAs resistance genes (Suls) over time but also be applied to reveal the relationships between the proliferation of Suls and important factors (i.e., concentrations and chemical structures). Moreover, the Delta A(R)-based QSARs model indicated that bioavailability and the frequency of conjugative transfer, rather than the ability of induced mutations in bacteria, tend to be key processes of the characteristics of the proliferation of Suls. Therefore, Delta A(R) is a useful parameter to perform environmental risk assessments of ARG proliferation in the environment.
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