期刊
SCIENCE CHINA-CHEMISTRY
卷 63, 期 9, 页码 1272-1280出版社
SCIENCE PRESS
DOI: 10.1007/s11426-020-9780-8
关键词
poly(L-lysine); DC vaccine; NIR-II fluorescence tracking
资金
- National Natural Science Foundation of China [21574064, 21674048, 21671109, 21604042]
- Primary Research & Development Plan of Jiangsu Province [BE2016770]
- Synergetic Innovation Center for Organic Electronics and Information Displays
- Priority Academic Program Development of Jiangsu Higher Education Institutions [YX030003]
Dendritic cell (DC) vaccine is an effective strategy for cancer immunotherapy by carrying antigen into DCs and migrating these DCs to drain lymph nodes after inoculation. In this article, second near-infrared window (NIR-II) fluorescent nanoparticles have been used to uptake antigen and activate DCs. Ovalbumin (OVA), an antigen for immunization, can be loaded on the surface of these NIR-II fluorescent nanoparticles via electrostatic interaction by virtue of their functionalized poly(L-lysine) (PLL), which exhibits biocompatibility and strong selective interaction with OVA. In addition, these antigen-loaded complexes can efficiently be engulfed by immature DCs to induce DC maturation and cytokine secretion. After subcutaneous injection, highly sensitive NIR-II fluorescence signal from nanoparticles indicates that nanoparticle-labeled DCs can successfully migrate into lymph nodesin vivo, showing great promise in immunotherapy against cancer.
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