期刊
SCIENCE
卷 368, 期 6496, 页码 1204-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aay4631
关键词
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资金
- European Research Council [787340]
- Human Frontier Science Program [RGP0019]
- Conseil regional de nouvelle Aquitaine
- CNRS
- Fondation pour la Recherche Medicale
- Agence Nationale de la Recherche
- European Research Council (ERC) [787340] Funding Source: European Research Council (ERC)
Regulation of neurotransmitter receptor content at synapses is achieved through a dynamic equilibrium between biogenesis and degradation pathways, receptor stabilization at synaptic sites, and receptor trafficking in and out synapses. In the past 20 years, the movements of receptors to and from synapses have emerged as a series of highly regulated processes that mediate postsynaptic plasticity. Our understanding of the properties and roles of receptor movements has benefited from technological advances in receptor labeling and tracking capacities, as well as from new methods to interfere with their movements. Focusing on two key glutamatergic receptors, we review here our latest understanding of the characteristics of receptor movements and their role in tuning the efficacy of synaptic transmission in health and brain disease.
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