期刊
SCIENCE
卷 368, 期 6497, 页码 1330-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.abb2751
关键词
-
资金
- NIH [NS97344, NS105324, NS101843, MH115554, K99 NS101057, NS089521]
- NSF [GRFP 2014177995]
- James S. McDonnell Foundation
- Edward R. and Anne G. Lefler Center for Neurodegenerative Disorders
Meissner corpuscles are mechanosensory end organs that densely occupy mammalian glabrous skin. We generated mice that selectively lacked Meissner corpuscles and found them to be deficient in both perceiving the gentlest detectable forces acting on glabrous skin and fine sensorimotor control. We found that Meissner corpuscles are innervated by two mechanoreceptor subtypes that exhibit distinct responses to tactile stimuli. The anatomical receptive fields of these two mechanoreceptor subtypes homotypically tile glabrous skin in a manner that is offset with respect to one another. Electron microscopic analysis of the two Meissner afferents within the corpuscle supports a model in which the extent of lamellar cell wrappings of mechanoreceptor endings determines their force sensitivity thresholds and kinetic properties.
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