4.5 Review

Role of the RNA-binding protein La in cancer pathobiology

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La proteins couple use of sequence-specific and non-specific binding modes to engage RNA substrates

Mark A. Bayfield et al.

Summary: La protein shuttles between the nucleus and cytoplasm to bind nascent RNA polymerase III transcripts and mRNAs using different binding modes, protecting RNA precursors and promoting maturation and translation. Studies have shown that La proteins utilize multiple binding modes beyond the well-characterized UUU-3' end recognition, expanding our understanding of their RNA chaperone activity.

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The La-related proteins: structures and interactions of a versatile superfamily of RNA-binding proteins

Anne-Catherine Dock-Bregeon et al.

Summary: The La-related proteins (LaRPs) are an ancient superfamily of RNA-binding proteins that orchestrate the main fates of RNA through a complex network of protein-RNA and protein-protein interactions. Recent studies have revealed that LaRPs have evolved unique mechanisms of RNA recognition involving structured domains and disordered regions, working together to achieve RNA substrate discrimination. This review highlights our current understanding of the structure-function relationship within the LaRP superfamily.

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Human La binds mRNAs through contacts to the poly(A) tail

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Novel RNA chaperone domain of RNA-binding protein La is regulated by AKT phosphorylation

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LARP1 post-transcriptionally regulates mTOR and contributes to cancer progression

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RNA Chaperone Activity of Human La Protein Is Mediated by Variant RNA Recognition Motif

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La enhances IRES-mediated translation of laminin B1 during malignant epithelial to mesenchymal transition

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Roles of individual domains in the function of DHX29, an essential factor required for translation of structured mammalian mRNAs

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DNA damage and eIF4G1 in breast cancer cells reprogram translation for survival and DNA repair mRNAs

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Conservation of the relative tRNA composition in healthy and cancerous tissues

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Identification of an mRNP Complex Regulating Tumorigenesis at the Translational Elongation Step

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The RNA-binding protein La contributes to cell proliferation and CCND1 expression

G. Sommer et al.

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An intrinsically disordered C terminus allows the La protein to assist the biogenesis of diverse noncoding RNA precursors

Nathan J. Kucera et al.

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Transfer RNA-derived fragments: origins, processing, and functions

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Addiction to protein kinase CK2: A common denominator of diverse cancer cells?

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La/SSB ribonucleoprotein levels increased in transformed cells

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tRNA over-expression in breast cancer and functional consequences

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Akt phosphorylation of La regulates specific mRNA translation in glial progenitors

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A comprehensive analysis of the La-motif protein superfamily

Cecile Bousquet-Antonelli et al.

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Laurence Dubrez-Daloz et al.

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Association of guanine nucleotide-exchange protein BIG1 in HepG2 cell nuclei with nucleolin, U3 snoRNA, and fibrillarin

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Splicing mediates the activity of four putative cellular internal ribosome entry sites

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Identification of internal ribosome entry segment (IRES)-trans-acting factors for the Myc family of IRESs

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La autoantigen translocates to cytoplasm after cleavage during granzyme B-mediated cytotoxicity

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Sumoylation in axons triggers retrograde transport of the RNA-binding protein La

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RNA regulons: coordination of post-transcriptional events

Jack D. Keene

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Conservation of a masked nuclear export activity of La proteins and its effects on tRNA maturation

Mark A. Bayfield et al.

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The leader region of Laminin B1 mRNA confers cap-independent translation

Michaela Petz et al.

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Impact of protein kinase PKR in cell biology:: from antiviral to antiproliferative action

M. A. Garcia et al.

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RNA chaperone activity of protein components of human Ro RNPs

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M Holcik et al.

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Structural analysis of cooperative RNA binding by the La motif and central RRM domain of human La protein

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Assembly and maturation of the U3 snoRNP in the nucleoplasm in a large dynamic multiprotein complex

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BCL-2 translation is mediated via internal ribosome entry during cell stress

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Nonphosphorylated human La antigen interacts with nucleolin at nucleolar sites involved in rRNA biogenesis

RV Intine et al.

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Nuclear trafficking of La protein depends on a newly identified nucleolar localization signal and the ability to bind RNA

S Horke et al.

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A La protein requirement for efficient pre-tRNA folding

G Chakshusmathi et al.

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La protein is associated with terminal oligopyrimidine mRNAs in actively translating polysomes

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BCR/ABL activates mdm2 rnRNA translation via the La antigen

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Nucleolin associates with a subset of the human Ro ribonucleoprotein complexes

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Laminin isoforms in tumor invasion, angiogenesis and metastasis

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JA Diehl

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La autoantigen enhances translation of BiP mRNA

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La autoantigen is cleaved in the COOH terminus and loses the nuclear localization signal during apoptosis

K Ayukawa et al.

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Precursors to the U3 small nucleolar RNA lack small nucleolar RNP proteins but are stabilized by La binding

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Control of transfer RNA maturation by phosphorylation of the human La antigen on Serine 366

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