期刊
RESEARCH IN VETERINARY SCIENCE
卷 131, 期 -, 页码 38-42出版社
ELSEVIER SCI LTD
DOI: 10.1016/j.rvsc.2020.04.004
关键词
Porcine reproductive and respiratory syndrome virus (PRRSV); ORF5 gene; Genetic diversity; MLV-derived viruses
资金
- Natural Science Foundation of Jiangsu Province [BK20170492]
- National Natural Science Foundation of China [31802172, 31602054]
- China Postdoctoral Science Foundation [2016M590510]
- Science and Innovation Foundation of Yangzhou University [X20190669]
- Jiangsu Co-innovation Center for Prevention and Control of Important Animal Infectious Diseases and Zoonoses
- Priority Academic Program Development of Jiangsu Higher Education Institutions (PAPD)
- High Talent Supporting Program of Yangzhou University
High genetic diversity and limited cross-protection are two major reasons for ineffective control of porcine reproductive and respiratory syndrome virus (PRRSV) infection. Therefore, it's important to dynamically monitor the prevalence of PRRSV for adopting appropriate control strategy. In this study, we analyzed PRRSV infection by detecting 712 clinical samples collected from 2016 to 2019 in China. Totally 100 samples were detected as PRRSV positive, including 2 and 98 samples were infected with PRRSV1 and PRRSV2, respectively. In addition, two out of the 98 PRRSV2 positive samples were co-infected with two distinct viruses. ORF5-based phylogenetic analysis showed that JXA1-like HP-PRRSV2 (lineage 8) and NADC30-like PRRSV2 (lineage 1) isolates are currently predominant, but QYYZ-like PRRSV2, CH-1a-like PRRSV2 and PRRSV1 isolates also co-exist in Chinese swine herds. In addition, two commercial MLV-derived viruses (TJM-F92-like and JXA1-R-like) were frequently detected. GP5 alignment also detected insertion and deletion in the extravirion domain. Our study presents the up-to-date PRRSV infection status and highlights the high genetic diversity of PRRSV currently circulating in China.
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