4.4 Article

Naringin regulates erectile dysfunction by abolition of apoptosis and inflammation through NOS/cGMP/PKG signalling pathway on exposure to Bisphenol-A in hypertensive rat model

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REPRODUCTIVE TOXICOLOGY
卷 95, 期 -, 页码 123-136

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PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.reprotox.2020.05.007

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Naringin; Erectile dysfunction; Hypertension; Apoptosis; Inflammation; Environmental toxicant; Rat model

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This study investigated the effect of naringin (NRG) on extracellular metabolism of ATP through the NOS/cGMP/ PKG signaling pathway induced by Nco-nitro-L-arginine methyl ester hydrochloride (L -NAME) on exposure to Bisphenol-A (BPA) in penis. Fifty-six adult male albino rats were randomly distributed into eight (n = 7) groups. Group I: control animals, Group II was treated with 40 mg/kg L -NAME, Group III was treated with 50 mg/kg BPA, Group IV was treated with 40 mg/kg L -NAME + 50 mg/kg BPA. Group V was administered with 40 mg/kg L -NAME + 80 mg/kg NRG. Group VI was administered with 50 mg/kg BPA + 80 mg/kg NRG. Group VII was administered with 40 mg/kg L -NAME +50 mg/kg BPA + 80 mg/kg NRG. Lastly, group VIII was treated with 80 mg/kg NRG for 14 days. NRG prevented hypertension and erectile dysfunction by inhibiting the activities of angiotensin-converting enzymes, arginase, and phosphodiesterase-5(1) (PDE-5(1)) with corresponding down-regulation of inflammatory markers including TNF-alpha and IL-B. Additionally, hypertensive erectile dysfunction was remarkably prevented by NRG as manifested by the declined activities of AChE, MAO-A and enzymes of ATP hydrolysis (ATPase, ADPase, AMPase and ADA) with resultant increase in NO level. Also, penile expression of antigen presenting cells, CD43 transcript, caspace-9 and tumor suppressor P53 proteins were repressed on treatment with NRG. This study validates the hypothesis that NRG may be a valuable remedy in abrogating penile inflammatory markers, apoptosis and enzymes of ATP-hydrolysis via NOS/cGMP/PKG signaling pathways in hypertensive rat model on exposure to environmental toxicant.

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