期刊
REGENERATIVE MEDICINE
卷 15, 期 6, 页码 1749-1759出版社
FUTURE MEDICINE LTD
DOI: 10.2217/rme-2019-0136
关键词
acute myocardial infarction; cardiac fibrosis; exosomes; mesenchymal stem cells; miR-19a; 19b
Aim:We aimed to investigate the protection of exogenous miR-19a/19b with bone marrow-derived mesenchymal stem cell (BM-MSC) transplantation on cardiac function and inhibition of fibrosis in myocardial infarction (MI).Materials & methods:BM-MSC-derived exosomes were used to deliver miR-19a/19b (exo/miR-19a/19b) to the cultured cardiac HL-1 cells, and the apoptosis of cells were evaluated. Exo/miR-19a/19b and BM-MSCs were also transplanted to anin vivoMI mouse model. The recovery of cardiac function was assessed and the level of cardiac fibrosis was determined.Results:Exo/miR-19a/19b and MSCs reduced the area of cardiac fibrosis in the heart tissue in the mouse MI model. Using BM-MSC-derived exosomes as a vehicle, miR-19a/19b significantly suppressed the apoptosis of cardiac HL-1 cells. The combination of Exo/miR-19a/19b and MSC transplantation significantly enhanced the recovery of cardiac function and reduced cardiac fibrosis in the MI model.Conclusion:Our study provides an effective regenerative intervention strategy to attenuate the damage of MI.
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