期刊
PSYCHOLOGICAL MEDICINE
卷 52, 期 3, 页码 467-475出版社
CAMBRIDGE UNIV PRESS
DOI: 10.1017/S003329172000210X
关键词
Bipolar disorder; BMI; circadian rhythm; cognition; physical activity; sleep
This study suggests an association between sleep abnormalities and cognition in patients with bipolar disorder, with little or no relationship with physical activity, BMI, and circadian rhythm.
Background. Cognitive deficits affect a significant proportion of patients with bipolar disorder (BD). Problems with sustained attention have been found independent of mood state and the causes are unclear. We aimed to investigate whether physical parameters such as activity levels, sleep, and body mass index (BMI) may be contributing factors. Methods. Forty-six patients with BD and 42 controls completed a battery of neuropsychological tests and wore a triaxial accelerometer for 21 days which collected information on physical activity, sleep, and circadian rhythm. Ex-Gaussian analyses were used to characterise reaction time distributions. We used hierarchical regression analyses to examine whether physical activity, BMI, circadian rhythm, and sleep predicted variance in the performance of cognitive tasks. Results. Neither physical activity, BMI, nor circadian rhythm predicted significant variance on any of the cognitive tasks. However, the presence of a sleep abnormality significantly predicted a higher intra-individual variability of the reaction time distributions on the Attention Network Task. Conclusions. This study suggests that there is an association between sleep abnormalities and cognition in BD, with little or no relationship with physical activity, BMI, and circadian rhythm.
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