期刊
PSYCHIATRY AND CLINICAL NEUROSCIENCES
卷 74, 期 10, 页码 527-534出版社
WILEY
DOI: 10.1111/pcn.13083
关键词
clinical high risk; electroencephalogram; longitudinal; P300; schizophrenia
资金
- National Institute of Mental Health [K05MH070047, R01MH50747, R01MH40799, R01MH052807, CIDAR P50MH080272]
- Strategic Young Researcher Overseas Visits Program for Accelerating Brain Circulation [S2208]
- Japanese Ministry of Education, Culture, Sports, Science, and Technology [JP22791129, JP 15K19735, JP 17K16385, JP 19K08049, JP 22791129, JP 15K09836, JP 18K07604, JP 17H02624, JP 19H03579, JP 19H00630]
- Agency for Medical Research and Development [JP20dm0207069]
- Brain Science Foundation
- Takeda Science Foundation
- Schizophrenia International Research Society
Aim We previously reported abnormal P300 and N200 in a visual oddball task, and progressive P300 amplitude reduction at 1-year follow-up in patients with first-episode schizophrenia. P300 reduction as well as intact P1/N1 were also observed in clinical high-risk subjects (CHR), but whether or not these components change over time is unknown. This study evaluates, longitudinally, the visual P300, as well as P1, N1, and N200, in CHR. Methods Visual event-related potentials (ERP) were recorded twice, once at baseline and once at 1-year follow-up in CHR (n= 19) and healthy comparison subjects (HC;n= 28). Participants silently counted infrequent target stimuli ('x') among standard stimuli ('y') presented on the screen while the 64-channel electroencephalogram was recorded. Results No CHR converted to psychosis from baseline to 1-year follow-up in this study. Visual P300 amplitude was reduced and the latency was delayed significantly in CHR at both time points compared with HC. Furthermore, CHR subjects who had more positive symptoms showed more amplitude reduction at both time points. P1, N1, and N200 did not differ between groups. Conclusion Visual P300 amplitude was found to be reduced in CHR individuals compared with HC. We note that this finding is in subjects who did not convert to psychosis at 1-year follow-up. The association between visual P300 amplitude and symptoms suggests that for CHR who often experience clinical symptoms and seek medical care, visual P300 may be an important index that reflects the pathophysiological impairment underlying such clinical states.
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