期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 117, 期 32, 页码 19590-19598出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1921909117
关键词
lateral hypothalamus; REM sleep; feeding; calcium imaging; optogenetics
资金
- Human Frontier Science Program [RGY0076/2012]
- Inselspital University Hospital
- European Research Council [CoG-725850]
- Swiss National Science Foundation
- University of Bern
- German Research Foundation [GA 2410/1-1]
During rapid eye movement (REM) sleep, behavioral unresponsiveness contrasts strongly with intense brain -wide neural network dynamics. Yet, the physiological functions of this cellular activation remain unclear. Using in vivo calcium imaging in freely behaving mice, we found that inhibitory neurons in the lateral hypothalamus (LHvgat) show unique activity patterns during feeding that are reactivated during REM, but not non-REM, sleep. REM sleep-specific optogenetic silencing of LHvgat cells induced a reorganization of these activity patterns during subsequent feeding behaviors accompanied by decreased food intake. Our findings provide evidence for a role for REM sleep in the maintenance of cellular representations of feeding behavior.
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