相关参考文献
注意:仅列出部分参考文献,下载原文获取全部文献信息。SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor
Markus Hoffmann et al.
CELL (2020)
A highly conserved cryptic epitope in the receptor binding domains of SARS-CoV-2 and SARS-CoV
Meng Yuan et al.
SCIENCE (2020)
Characterization of spike glycoprotein of SARS-CoV-2 on virus entry and its immune cross-reactivity with SARS-CoV
Xiuyuan Ou et al.
NATURE COMMUNICATIONS (2020)
A family of PIKFYVE inhibitors with therapeutic potential against autophagy-dependent cancer cells disrupt multiple events in lysosome homeostasis
Gaurav Sharma et al.
AUTOPHAGY (2019)
Arbidol and Other Low-Molecular-Weight Drugs That Inhibit Lassa and Ebola Viruses
C. E. Hulseberg et al.
JOURNAL OF VIROLOGY (2019)
The Phosphoinositide Kinase PlKfyve Promotes Cathepsin-S-Mediated Major Histocompatibility Complex Class II Antigen Presentation
Maksim V. Baranov et al.
ISCIENCE (2019)
Identification of Combinations of Approved Drugs With Synergistic Activity Against Ebola Virus in Cell Cultures
Julie Dyall et al.
JOURNAL OF INFECTIOUS DISEASES (2018)
Ebola virus requires phosphatidylinositol (3,5) bisphosphate production for efficient viral entry
Shirley Qiu et al.
VIROLOGY (2018)
Identification of Novel Vacuolin-1 Analogues as Autophagy Inhibitors by Virtual Drug Screening and Chemical Synthesis
Chang Chen et al.
MOLECULES (2017)
The phosphatidylinositol-3-phosphate 5-kinase inhibitor apilimod blocks filoviral entry and infection
Elizabeth A. Nelson et al.
PLOS NEGLECTED TROPICAL DISEASES (2017)
Identification of apilimod as a first-in-class PIKfyve kinase inhibitor for treatment of B-cell non-Hodgkin lymphoma
Sophia Gayle et al.
BLOOD (2017)
Vacuolin-1 inhibits autophagy by impairing lysosomal maturation via PIKfyve inhibition
Osamu Sano et al.
FEBS LETTERS (2016)
Identification and Characterization of a Novel Broad-Spectrum Virus Entry Inhibitor
Yi-ying Chou et al.
JOURNAL OF VIROLOGY (2016)
Direct Visualization of Ebola Virus Fusion Triggering in the Endocytic Pathway
Jennifer S. Spence et al.
MBIO (2016)
Protease inhibitors targeting coronavirus and filovirus entry
Yanchen Zhou et al.
ANTIVIRAL RESEARCH (2015)
Tracking the Fate of Genetically Distinct Vesicular Stomatitis Virus Matrix Proteins Highlights the Role for Late Domains in Assembly
Timothy K. Soh et al.
JOURNAL OF VIROLOGY (2015)
Vacuolin-1 potently and reversibly inhibits autophagosome-lysosome fusion by activating RAB5A
Yingying Lu et al.
AUTOPHAGY (2014)
Characterization of IIPS34-IN1, a selective inhibitor of Vps34, reveals that the phosphatidylinositol 3-phosphate-binding SGK3 protein kinase is a downstream target of class Ill phosphoinositide 3-kinase
Ruzica Bago et al.
BIOCHEMICAL JOURNAL (2014)
Lassa virus entry requires a trigger-induced receptor switch
Lucas T. Jae et al.
SCIENCE (2014)
PIKfyve, a Class III PI Kinase, Is the Target of the Small Molecular IL-12/IL-23 Inhibitor Apilimod and a Player in Toll-like Receptor Signaling
Xinming Cai et al.
CHEMISTRY & BIOLOGY (2013)
Uptake of Rabies Virus into Epithelial Cells by Clathrin-Mediated Endocytosis Depends upon Actin
Silvia Piccinotti et al.
JOURNAL OF VIROLOGY (2013)
Genome engineering using the CRISPR-Cas9 system
F. Ann Ran et al.
NATURE PROTOCOLS (2013)
A phase IIa, randomized, double-blind, placebo-controlled trial of apilimod mesylate, an interleukin-12/interleukin-23 inhibitor, in patients with rheumatoid arthritis
Sarah Krausz et al.
ARTHRITIS AND RHEUMATISM (2012)
The First Five Seconds in the Life of a Clathrin-Coated Pit
Emanuele Cocucci et al.
CELL (2012)
Apilimod Inhibits the Production of IL-12 and IL-23 and Reduces Dendritic Cell Infiltration in Psoriasis
Yumiko Wada et al.
PLOS ONE (2012)
The VP1 subunit of JC polyomavirus recapitulates early events in viral trafficking and is a novel tool to study polyomavirus entry
Christian D. S. Nelson et al.
VIROLOGY (2012)
A Transmembrane Serine Protease Is Linked to the Severe Acute Respiratory Syndrome Coronavirus Receptor and Activates Virus Entry
Ana Shulla et al.
JOURNAL OF VIROLOGY (2011)
Evidence that TMPRSS2 Activates the Severe Acute Respiratory Syndrome Coronavirus Spike Protein for Membrane Fusion and Reduces Viral Control by the Humoral Immune Response
Ilona Glowacka et al.
JOURNAL OF VIROLOGY (2011)
Small molecule inhibitors reveal Niemann-Pick C1 is essential for Ebola virus infection
Marceline Cote et al.
NATURE (2011)
Ebola virus entry requires the cholesterol transporter Niemann-Pick C1
Jan E. Carette et al.
NATURE (2011)
Old World Arenaviruses Enter the Host Cell via the Multivesicular Body and Depend on the Endosomal Sorting Complex Required for Transport
Giulia Pasqual et al.
PLOS PATHOGENS (2011)
Randomized, Double-Blind, Placebo-Controlled Trial of the Oral Interleukin-12/23 Inhibitor Apilimod Mesylate for Treatment of Active Crohn's Disease
Bruce E. Sands et al.
INFLAMMATORY BOWEL DISEASES (2010)
A Forward Genetic Strategy Reveals Destabilizing Mutations in the Ebolavirus Glycoprotein That Alter Its Protease Dependence during Cell Entry
Anthony C. Wong et al.
JOURNAL OF VIROLOGY (2010)
Efficient Activation of the Severe Acute Respiratory Syndrome Coronavirus Spike Protein by the Transmembrane Protease TMPRSS2
Shutoku Matsuyama et al.
JOURNAL OF VIROLOGY (2010)
A selective PIKfyve inhibitor blocks PtdIns(3,5) P2 production and disrupts endomembrane transport and retroviral budding
Harold B. J. Jefferies et al.
EMBO REPORTS (2008)
Core protein machinery for mammalian phosphatidylinositol 3,5-bisphosphate synthesis and turnover that regulates the progression of endosomal transport - Novel sac phosphatase joins the arpikfyve-pikfyve complex
Diego Sbrissa et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The mammalian phosphatidylinositol 3-phosphate 5-kinase (PIKfyve) regulates endosome-to-TGN retrograde transport
Anna C. Rutherford et al.
JOURNAL OF CELL SCIENCE (2006)
A phase 1/2A trial of STA 5326, an oral interleukin-12/23 inhibitor, in patients with active moderate to severe Crohn's disease
Robert Burakoff et al.
INFLAMMATORY BOWEL DISEASES (2006)
SARS coronavirus, but not human coronavirus NL63, utilizes cathepsin L to infect ACE2-expressing cells
IC Huang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Coincidence detection in phosphoinositide signaling
JG Carlton et al.
TRENDS IN CELL BIOLOGY (2005)
Inhibitors of cathepsin L prevent severe acute respiratory syndrome coronavirus entry
G Simmons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2005)
Endosome-to-cytosol transport of viral nucleocapsids
I Le Blanc et al.
NATURE CELL BIOLOGY (2005)
Endosomal proteolysis of the Ebola virus glycoprotein is necessary for infection
K Chandran et al.
SCIENCE (2005)
Characterization of severe acute respiratory syndrome-associated coronavirus (SARS-CoV) spike glycoprotein-mediated viral entry
G Simmons et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
The small chemical vacuolin-1 inhibits Ca2+-dependent lysosomal exocytosis but not cell resealing
J Cerny et al.
EMBO REPORTS (2004)
Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40
OC Ikonomov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Functional dissection of lipid and protein kinase signals of PIKfyve reveals the role of PtdIns 3,5-P2 production for endomembrane integrity
OC Ikonomov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Mammalian cell morphology and endocytic membrane homeostasis require enzymatically active phosphoinositide 6-kinase PIKfyve
OC Ikonomov et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)