期刊
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
卷 117, 期 25, 页码 14473-14481出版社
NATL ACAD SCIENCES
DOI: 10.1073/pnas.1919887117
关键词
tanycyte; hypothalamus; food intake; arcuate nucleus; ATP
资金
- Medical Research Council [MR/J003786/1]
- BBSRC [BB/M022692/1] Funding Source: UKRI
- MRC [MR/J003786/1, MC_PC_15070] Funding Source: UKRI
Hypothalamic tanycytes are chemosensitive glial cells that contact the cerebrospinal fluid in the third ventricle and send processes into the hypothalamic parenchyma. To test whether they can activate neurons of the arcuate nucleus, we targeted expression of a Ca 2+ -permeable channelrhodopsin (CatCh) specifically to tany- cytes. Activation of tanycytes ex vivo depolarized orexigenic (neu- ropeptide Y/agouti-related protein; NPY/AgRP) and anorexigenic (proopiomelanocortin; POMC) neurons via an ATP -dependent mechanism. In vivo, activation of tanycytes triggered acute hyper- phagia only in the fed state during the inactive phase of the light -dark cycle.
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