Uric Acid as a Naturally Biodegradable and Reusable Catalyst for the Convenient and Eco-Safe Synthesis of Biologically Active Pyran Annulated Heterocyclic Systems

A naturally biodegradable, reusable, and eco-safe catalyst,i.e.,uric acid was developed and exploited for the green, facile and economical one-pot synthesis of pyran annulated heterocyclic systems from starting materials. This method gives an insight into the credibility of pathway followed by the aforementioned green and reusable catalyst in aiding the heterocyclic compounds formation. High atom economy, cleaner reaction profile, simple column-free work up condition, shorter reaction times, high to excellent yields, eco-safe and high catalytic activity make this present procedure an interesting alternative to the multistep approaches.

Automated summary

A naturally biodegradable, reusable, and eco-safe catalyst called uric acid has been developed for the green, facile and economical one-pot synthesis of pyran annulated heterocyclic systems. This study provides insight into the reliability of the catalyst in aiding the formation of heterocyclic compounds. The method offers high atom economy, cleaner reaction profile, simple column-free work up condition, shorter reaction times, high to excellent yields, eco-safety, and high catalytic activity, making it an interesting alternative to multistep approaches.