4.5 Article

A rationale for blocking thromboinflammation in COVID-19 with Btk inhibitors

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Low-dose Btk inhibitors selectively block platelet activation by CLEC-2

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Summary: In this study, it was demonstrated that Btk inhibitors selectively block the activation of human platelets through CLEC-2 as opposed to GPVI, suggesting a potential therapeutic use at low doses in patients with thrombo-inflammatory diseases.

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