期刊
PHYTOCHEMISTRY
卷 174, 期 -, 页码 -出版社
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.phytochem.2020.112348
关键词
Daphne genkwa Siebold et Zucc.; Thymelaeaceae; Sesquiterpenoid; Anti-inflammatory activity
资金
- National Nature Science Foundation of China [81872766, 81573319]
- Young and Middle-aged Science and Technology Innovative Talent Support Program of Shenyang City [RC180250]
- Career Development Support Plan for Young and Middle-aged Teachers in Shenyang Pharmaceutical University [ZQN2018006]
- Project of Innovation Team Foundation [LT2015027]
Six undescribed sesquiterpenoids, including three acorane-type sesquiterpenoids (daphneaines A-C), three guaiane-type sesquiterpenoids (daphneaines E-G) and three known analogues were isolated from the roots of Daphne genkwa Siebold a Zucc. Their gross structures were elucidated by comprehensive spectroscopic analyses. The relative configurations of daphneaines A-C were determined by NOESY experiments. In addition, the relative configuration of daphneaine G was elucidated by performing a quantum chemical calculation of the NMR chemical shifts coupled with an advanced statistical procedure DP4+. The comparison of experimental and calculated electronic circular dichroism (ECD) data led to the establishment of the absolute configurations of daphneaines A-G. All isolates were tested for their inhibitory activity towards the LPS-induced NO production in RAW 264.7 macrophages, and daphneaine F showed inhibitory effect on NO production with an IC50 value of 35.68 +/- 3.18 mu M.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据