期刊
PHYTOCHEMICAL ANALYSIS
卷 32, 期 2, 页码 198-205出版社
WILEY
DOI: 10.1002/pca.2965
关键词
network module; network pharmacology; neuroendocrine immunomodulation; phytochemical information; Si-Wu decoction
资金
- Science and Technology Development Fund of Macao SAR [0096-2019-A2]
- Universidade de Macau [MYRG2019-00011-ICMS]
The study utilized emerging network pharmacology to explore the holistic molecular evidence of Si-Wu decoction (SWD). Through the analysis of compound similarity (CS) network and target-(pathway)-target (TPT) network, the phytochemical profile of SWD and its molecular target profile were demonstrated. The topological analysis of TPT network revealed the holistic property of SWD in neuroendocrine immunomodulation (NIM) perspective, with potential active ingredients being primarily identified through network analysis.
Introduction Emerging network pharmacology (NP) combines phytochemical information with bioinformatics tools allowing herbal formulae to be illustrated holistically in the context of phytochemical basis and therapeutic mechanisms. Objective This study attempted to explore the holistic molecular evidence of herbal formula Si-Wu decoction (SWD) by using the method of NP. Material and method Databases of traditional medicines combined with PubChem, SciFinder, SEA, STRING, and KEGG were employed to gather information for establishing the compound similarity (CS) network and the target-(pathway)-target (TPT) network. Gephi software was applied to visualise the networks, with further module-based and node-based network topological analysis. Moreover, the approved drugs and shortest path analysis were used to validate the TPT network. Results The CS network presented the phytochemical profile of SWD, including the major compound groups of iridoid glycosides, glycosides, phthalide lactones, phenylpropanoids, and monoterpenoids. Furthermore, the topological analysis of TPT network depicted the holistic property of SWD in interpretable neuroendocrine immunomodulation (NIM) perspective, and the node degree analysis indicated a closer connection of SWD with endocrine or metabolism system. Moreover, by combing the analysis of the CS network and TPT network, potential active ingredients could be primarily identified. Conclusion The phytochemical profile and molecular target profile, which might pave the way for an understanding of SWD in modern science and provide a reference for relevant quality research and evaluation, were demonstrated by network analysis. Moreover, the methods could be further applied to discover the phytochemical or biomolecular evidence with distinct advantages in dealing with the tremendous separated information.
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