期刊
PHYSIOLOGY
卷 35, 期 4, 页码 222-233出版社
AMER PHYSIOLOGICAL SOC
DOI: 10.1152/physiol.00039.2019
关键词
hypoxia; heart failure; remodeling
类别
资金
- National Heart, Lung, and Blood Institute [HL-073859, HL-126514]
Exposure to hypoxia increases pulmonary vascular resistance, leading to elevated pulmonary arterial pressure and, potentially, right heart failure. Vascular remodeling is an important contributor to the increased pulmonary vascular resistance. Hyperproliferation of smooth muscle, endothelial cells, and fibroblasts, and deposition of extracellular matrix lead to increased wall thickness, extension of muscle into normally non-muscular arterioles, and vascular stiffening. This review highlights intrinsic and extrinsic modulators contributing to the remodeling process.
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