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Interactions between Diet, Bile Acid Metabolism, Gut Microbiota, and Inflammatory Bowel Diseases
Suzanne Devkota et al.
DIGESTIVE DISEASES (2015)
Bile Acids Trigger GLP-1 Release Predominantly by Accessing Basolaterally Located G Protein-Coupled Bile Acid Receptors
Cheryl A. Brighton et al.
ENDOCRINOLOGY (2015)
Role of FXR in β-Cells of Lean and Obese Mice
Bjoern Schittenhelm et al.
ENDOCRINOLOGY (2015)
Efficacy of Obeticholic Acid in Patients With Primary Biliary Cirrhosis and Inadequate Response to Ursodeoxycholic Acid
Gideon M. Hirschfield et al.
GASTROENTEROLOGY (2015)
Taurolithocholic acid promotes intrahepatic cholangiocarcinoma cell growth via muscarinic acetylcholine receptor and EGFR/ERK1/2 signaling pathway
Sumet Amonyingcharoen et al.
INTERNATIONAL JOURNAL OF ONCOLOGY (2015)
Early Increases in Bile Acids Post Roux-en-Y Gastric Bypass Are Driven by Insulin-Sensitizing, Secondary Bile Acids
Vance L. Albaugh et al.
JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM (2015)
Ursodeoxycholic acid exerts farnesoid X receptor-antagonistic effects on bile acid and lipid metabolism in morbid obesity
Michaela Mueller et al.
JOURNAL OF HEPATOLOGY (2015)
New paradigms in the treatment of hepatic cholestasis: From UDCA to FXR, PXR and beyond
Ulrich Beuers et al.
JOURNAL OF HEPATOLOGY (2015)
Farnesoid X nuclear receptor ligand obeticholic acid for non-cirrhotic, non-alcoholic steatohepatitis (FLINT): a multicentre, randomised, placebo-controlled trial
Brent A. Neuschwander-Tetri et al.
LANCET (2015)
Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance
Sungsoon Fang et al.
NATURE MEDICINE (2015)
TGR5 and Immunometabolism: Insights from Physiology and Pharmacology
Alessia Perino et al.
TRENDS IN PHARMACOLOGICAL SCIENCES (2015)
Farnesoid X receptor inhibits glucagon-like peptide-1 production by enteroendocrine L cells
Mohamed-Sami Trabelsi et al.
NATURE COMMUNICATIONS (2015)
Intestine-selective farnesoid X receptor inhibition improves obesity-related metabolic dysfunction
Changtao Jiang et al.
NATURE COMMUNICATIONS (2015)
The response of patients with bile acid diarrhoea to the farnesoid X receptor agonist obeticholic acid
J. R. F. Walters et al.
ALIMENTARY PHARMACOLOGY & THERAPEUTICS (2015)
A dysregulated acetyl/SUMO switch of FXR promotes hepatic inflammation in obesity
Dong-Hyun Kim et al.
EMBO JOURNAL (2015)
Control of hepatocyte proliferation and survival by Fgf receptors is essential for liver regeneration in mice
Susagna Padrissa-Altes et al.
GUT (2015)
Prevention of Spontaneous Hepatocarcinogenesis in Farnesoid X Receptor-Null Mice by Intestinal-Specific Farnesoid X Receptor Reactivation
Chiara Degirolamo et al.
HEPATOLOGY (2015)
Intestinal farnesoid X receptor signaling promotes nonalcoholic fatty liver disease
Changtao Jiang et al.
JOURNAL OF CLINICAL INVESTIGATION (2015)
Thematic Review Series: Intestinal Lipid Metabolism: New Developments and Current Insights Intestinal transport and metabolism of bile acids
Paul A. Dawson et al.
JOURNAL OF LIPID RESEARCH (2015)
Bile Acid Accelerates ErbB2-Induced Pro-Tumorigenic Activities in Biliary Tract Cancer
Takuya Kitamura et al.
MOLECULAR CARCINOGENESIS (2015)
Protective effects of farnesoid X receptor (FXR) on hepatic lipid accumulation are mediated by hepatic FXR and independent of intestinal FGF15 signal
Johannes Schmitt et al.
LIVER INTERNATIONAL (2015)
Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile
Charlie G. Buffie et al.
NATURE (2015)
Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice
Daniel A. Briere et al.
PLOS ONE (2015)
Reversal of Endothelial Dysfunction by GPBAR1 Agonism in Portal Hypertension Involves a AKT/FOXOA1 Dependent Regulation of H2S Generation and Endothelin-1
Barbara Renga et al.
PLoS One (2015)
Importance of Large Intestine in Regulating Bile Acids and Glucagon-Like Peptide-1 in Germ-Free Mice
Felcy Pavithra Selwyn et al.
DRUG METABOLISM AND DISPOSITION (2015)
In Barrett's esophagus patients and Barrett's cell lines, ursodeoxycholic acid increases antioxidant expression and prevents DNA damage by bile acids
Sui Peng et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)
Fibroblast growth factor 15 deficiency impairs liver regeneration in mice
Bo Kong et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2014)
Activation of farnesoid X receptor (FXR) protects against fructose-induced liver steatosis via inflammatory inhibition and ADRP reduction
Xijun Liu et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2014)
Novel Mechanistic Insights into Ectodomain Shedding of EGFR Ligands Amphiregulin and TGF-α: Impact on Gastrointestinal Cancers Driven by Secondary Bile Acids
Nagaraj S. Nagathihalli et al.
CANCER RESEARCH (2014)
Separating Tumorigenicity from Bile Acid Regulatory Activity for Endocrine Hormone FGF19
Mei Zhou et al.
CANCER RESEARCH (2014)
Role of the Microbiota in Immunity and Inflammation
Yasmine Belkaid et al.
CELL (2014)
Cytoplasmic Tyrosine Phosphatase Shp2 Coordinates Hepatic Regulation of Bile Acid and FGF15/19 Signaling to Repress Bile Acid Synthesis
Shuangwei Li et al.
CELL METABOLISM (2014)
Comparative Metabolomics Reveals Endogenous Ligands of DAF-12, a Nuclear Hormone Receptor, Regulating C. elegans Development and Lifespan
Parag Mahanti et al.
CELL METABOLISM (2014)
Comparative Effects of Prolonged and Intermittent Stimulation of the Glucagon-Like Peptide 1 Receptor on Gastric Emptying and Glycemia
Mahesh M. Umapathysivam et al.
DIABETES (2014)
The Bile Acid Receptor TGR5 Activates the TRPA1 Channel to Induce Itch in Mice
TinaMarie Lieu et al.
GASTROENTEROLOGY (2014)
Farnesoid X receptor agonists attenuate colonic epithelial secretory function and prevent experimental diarrhoea in vivo
Magdalena S. Mroz et al.
GUT (2014)
Yin Yang 1 promotes hepatic steatosis through repression of farnesoid X receptor in obese mice
Yan Lu et al.
GUT (2014)
SIRT1 Controls Liver Regeneration by Regulating Bile Acid Metabolism Through Farnesoid X Receptor and Mammalian Target of Rapamycin Signaling
Juan L. Garcia-Rodriguez et al.
HEPATOLOGY (2014)
Glucose Sensing O-GlcNAcylation Pathway Regulates the Nuclear Bile Acid Receptor Farnesoid X Receptor (FXR)
Wahiba Berrabah et al.
HEPATOLOGY (2014)
TGR5 reduces macrophage migration through mTOR-induced C/EBPβ differential translation
Alessia Perino et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
Metformin interferes with bile acid homeostasis through AMPK-FXR crosstalk
Fleur Lien et al.
JOURNAL OF CLINICAL INVESTIGATION (2014)
G-Protein-Coupled Bile Acid Receptor 1 (GPBAR1, TGR5) Agonists Reduce the Production of Proinflammatory Cytokines and Stabilize the Alternative Macrophage Phenotype
Klemens Hoegenauer et al.
JOURNAL OF MEDICINAL CHEMISTRY (2014)
FXR is a molecular target for the effects of vertical sleeve gastrectomy
Karen K. Ryan et al.
NATURE (2014)
Beyond intestinal soap-bile acids in metabolic control
Folkert Kuipers et al.
NATURE REVIEWS ENDOCRINOLOGY (2014)
Bile Acid Flux Is Necessary for Normal Liver Regeneration
Willscott E. Naugler
PLOS ONE (2014)
A GPBAR1 (TGR5) Small Molecule Agonist Shows Specific Inhibitory Effects on Myeloid Cell Activation In Vitro and Reduces Experimental Autoimmune Encephalitis (EAE) In Vitro
Nuruddeen D. Lewis et al.
PLOS ONE (2014)
Dual Activation of the Bile Acid Nuclear Receptor FXR and G-Protein-Coupled Receptor TGR5 Protects Mice against Atherosclerosis
Shinobu Miyazaki-Anzai et al.
PLOS ONE (2014)
A nontumorigenic variant of FGF19 treats cholestatic liver diseases
Jian Luo et al.
SCIENCE TRANSLATIONAL MEDICINE (2014)
FXR agonist GW4064 alleviates endotoxin-induced hepatic inflammation by repressing macrophage activation
Jun Yao et al.
WORLD JOURNAL OF GASTROENTEROLOGY (2014)
Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection
Casey M. Theriot et al.
NATURE COMMUNICATIONS (2014)
Microbiota Modification with Probiotics Induces Hepatic Bile Acid Synthesis via Downregulation of the Fxr-Fgf15 Axis in Mice
Chiara Degirolamo et al.
CELL REPORTS (2014)
Central action of FGF19 reduces hypothalamic AGRP/NPY neuron activity and improves glucose metabolism
Genevieve Marcelin et al.
MOLECULAR METABOLISM (2014)
A mitochondrially targeted compound delays aging in yeast through a mechanism linking mitochondrial membrane lipid metabolism to mitochondrial redox biology
Michelle T. Burstein et al.
REDOX BIOLOGY (2014)
G Protein-Coupled Bile Acid Receptor 1 Stimulation Mediates Arterial Vasodilation through a KCa1.1 (BKCa)-Dependent Mechanisms
Ryan M. Fryer et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2014)
Mitochondrial membrane lipidome defines yeast longevity
Adam Beach et al.
AGING-US (2013)
Colesevelam suppresses hepatic glycogenolysis by TGR5-mediated induction of GLP-1 action in DIO mice
Matthew J. Potthoff et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Potent stimulation of fibroblast growth factor 19 expression in the human ileum by bile acids
Justine H. Zhang et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Activation of G protein-coupled bile acid receptor, TGR5, induces smooth muscle relaxation via both Epac- and PKA-mediated inhibition of RhoA/Rho kinase pathway
Senthilkumar Rajagopal et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2013)
Gut Microbiota Regulates Bile Acid Metabolism by Reducing the Levels of Tauro-beta-muricholic Acid, a Naturally Occurring FXR Antagonist
Sama I. Sayin et al.
CELL METABOLISM (2013)
Fibroblast Growth Factor-19 Action in the Brain Reduces Food Intake and Body Weight and Improves Glucose Tolerance in Male Rats
Karen K. Ryan et al.
ENDOCRINOLOGY (2013)
Cardiomyocyte-expressed farnesoid-X-receptor is a novel apoptosis mediator and contributes to myocardial ischaemia/reperfusion injury
Jun Pu et al.
EUROPEAN HEART JOURNAL (2013)
REVIEWS IN BASIC AND CLINICAL GASTROENTEROLOGY AND HEPATOLOGY
Gideon M. Hirschfield et al.
GASTROENTEROLOGY (2013)
The Receptor TGR5 Mediates the Prokinetic Actions of Intestinal Bile Acids and Is Required for Normal Defecation in Mice
Farzad Alemi et al.
GASTROENTEROLOGY (2013)
Efficacy and Safety of the Farnesoid X Receptor Agonist Obeticholic Acid in Patients With Type 2 Diabetes and Nonalcoholic Fatty Liver Disease
Sunder Mudaliar et al.
GASTROENTEROLOGY (2013)
Identification of fibroblast growth factor 15 as a novel mediator of liver regeneration and its application in the prevention of post-resection liver failure in mice
Iker Uriarte et al.
GUT (2013)
Bile acids induce arrhythmias in human atrial myocardium-implications for altered serum bile acid composition in patients with atrial fibrillation
Peter P. Rainer et al.
HEART (2013)
α5β1-integrins are sensors for tauroursodeoxycholic acid in hepatocytes
Holger Gohlke et al.
HEPATOLOGY (2013)
The Receptor TGR5 Protects the Liver From Bile Acid Overload During Liver Regeneration in Mice
Noemie Pean et al.
HEPATOLOGY (2013)
Acids Trigger Cholemic Nephropathy in Common Bile-Duct-Ligated Mice
Peter Fickert et al.
HEPATOLOGY (2013)
TGR5 signalling inhibits the production of pro-inflammatory cytokines by in vitro differentiated inflammatory and intestinal macrophages in Crohn's disease
Kazuaki Yoneno et al.
IMMUNOLOGY (2013)
Farnesoid X Receptor Expression Is Decreased in Colonic Mucosa of Patients with Primary Sclerosing Cholangitis and Colitis-associated Neoplasia
Joana Torres et al.
INFLAMMATORY BOWEL DISEASES (2013)
The Bile Acid Receptor TGR5 Does Not Interact with β-Arrestins or Traffic to Endosomes but Transmits Sustained Signals from Plasma Membrane Rafts
Dane D. Jensen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
SUMOylation of the Farnesoid X Receptor (FXR) Regulates the Expression of FXR Target Genes
Natarajan Balasubramaniyan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Bile Acid Receptor Activation Modulates Hepatic Monocyte Activity and Improves Nonalcoholic Fatty Liver Disease
Rachel H. McMahan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2013)
Positive Regulation of Osteogenesis by Bile Acid Through FXR
Sun Wook Cho et al.
JOURNAL OF BONE AND MINERAL RESEARCH (2013)
The TGR5 receptor mediates bile acid-induced itch and analgesia
Farzad Alemi et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
FGF19 action in the brain induces insulin-independent glucose lowering
Gregory J. Morton et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Hepatic glucose sensing is required to preserve β cell glucose competence
Pascal Seyer et al.
JOURNAL OF CLINICAL INVESTIGATION (2013)
Cirrhosis and other liver disease in cystic fibrosis
Thomas Flass et al.
JOURNAL OF CYSTIC FIBROSIS (2013)
Bile acid transporters and regulatory nuclear receptors in the liver and beyond
Emina Halilbasic et al.
JOURNAL OF HEPATOLOGY (2013)
Farnesoid X receptor activation increases cholesteryl ester transfer protein expression in humans and transgenic mice
Thomas Gautier et al.
JOURNAL OF LIPID RESEARCH (2013)
Farnesoid X Receptor Inhibits the Transcriptional Activity of Carbohydrate Response Element Binding Protein in Human Hepatocytes
Sandrine Caron et al.
MOLECULAR AND CELLULAR BIOLOGY (2013)
Obesity-induced gut microbial metabolite promotes liver cancer through senescence secretome
Shin Yoshimoto et al.
NATURE (2013)
The bile acid receptor, TGR5, regulates basal and cholinergic-induced secretory responses in rat colon
J. B. J. Ward et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2013)
Decreased hepatotoxic bile acid composition and altered synthesis in progressive human nonalcoholic fatty liver disease
April D. Lake et al.
TOXICOLOGY AND APPLIED PHARMACOLOGY (2013)
Microbiome remodelling leads to inhibition of intestinal farnesoid X receptor signalling and decreased obesity
Fei Li et al.
NATURE COMMUNICATIONS (2013)
Safety, Pharmacokinetics, and Pharmacodynamic Effects of a Selective TGR5 Agonist, SB-756050, in Type 2 Diabetes
Rebecca J. Hodge et al.
CLINICAL PHARMACOLOGY IN DRUG DEVELOPMENT (2013)
Direct methylation of FXR by Set7/9, a lysine methyltransferase, regulates the expression of FXR target genes
Natarajan Balasubramaniyan et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2012)
Molecular mechanisms underlying bile acid-stimulated glucagon-like peptide-1 secretion
H. E. Parker et al.
BRITISH JOURNAL OF PHARMACOLOGY (2012)
External biliary drainage and liver regeneration after major hepatectomy
R. Otao et al.
BRITISH JOURNAL OF SURGERY (2012)
Bile Acids Acutely Stimulate Insulin Secretion of Mouse β-Cells via Farnesoid X Receptor Activation and KATP Channel Inhibition
Martina Duefer et al.
DIABETES (2012)
The Role of Bile After Roux-en-Y Gastric Bypass in Promoting Weight Loss and Improving Glycaemic Control
Dimitri J. Pournaras et al.
ENDOCRINOLOGY (2012)
Glucocorticoid receptor mediates the gluconeogenic activity of the farnesoid X receptor in the fasting condition
Barbara Renga et al.
FASEB JOURNAL (2012)
Selective Activation of Nuclear Bile Acid Receptor FXR in the Intestine Protects Mice Against Cholestasis
Salvatore Modica et al.
GASTROENTEROLOGY (2012)
Conjugated bile acids activate the sphingosine-1-phosphate receptor 2 in primary rodent hepatocytes
Elaine Studer et al.
HEPATOLOGY (2012)
Crosstalk Between the Hepatologist and the Cardiologist: A Future Place for the Lithocholic Acid as a Coronary Atheroma Risk Factor?
Henri Duboc et al.
HEPATOLOGY (2012)
Antagonism of sphingosine 1-phosphate receptor 2 causes a selective reduction of portal vein pressure in bile duct-ligated rodents
Yuko Kageyama et al.
HEPATOLOGY (2012)
Mechanism of tissue-specific farnesoid X receptor in suppressing the expression of genes in bile-acid synthesis in mice
Bo Kong et al.
HEPATOLOGY (2012)
Promotion of Liver Regeneration/Repair by Farnesoid X Receptor in Both Liver and Intestine in Mice
Lisheng Zhang et al.
HEPATOLOGY (2012)
Bile acids induce monocyte differentiation toward interleukin-12 hypo-producing dendritic cells via a TGR5-dependent pathway
Riko Ichikawa et al.
IMMUNOLOGY (2012)
Nuclear Receptors HNF4α and LRH-1 Cooperate in Regulating Cyp7a1 in Vivo
Serkan Kir et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2012)
Bicarbonate and functional CFTR channel are required for proper mucin secretion and link cystic fibrosis with its mucus phenotype
Jenny K. Gustafsson et al.
JOURNAL OF EXPERIMENTAL MEDICINE (2012)
Loss of FXR Protects against Diet-Induced Obesity and Accelerates Liver Carcinogenesis in ob/ob Mice
Yanqiao Zhang et al.
MOLECULAR ENDOCRINOLOGY (2012)
Conjugated Bile Acids Associate with Altered Rates of Glucose and Lipid Oxidation after Roux-en-Y Gastric Bypass
M. Simonen et al.
OBESITY SURGERY (2012)
Gender-Divergent Profile of Bile Acid Homeostasis during Aging of Mice
Zidong Donna Fu et al.
PLOS ONE (2012)
Farnesoid X Receptor Induces Murine Scavenger Receptor Class B Type I via Intron Binding
Guodong Li et al.
PLOS ONE (2012)
Bile Acid Binding Resin Improves Metabolic Control through the Induction of Energy Expenditure
Mitsuhiro Watanabe et al.
PLOS ONE (2012)
Forkhead Box M1 (FoxM1) Gene Is a New STAT3 Transcriptional Factor Target and Is Essential for Proliferation, Survival and DNA Repair of K562 Cell Line
Andre L. Mencalha et al.
PLOS ONE (2012)
A Steroid Receptor-MicroRNA Switch Regulates Life Span in Response to Signals from the Gonad
Yidong Shen et al.
SCIENCE (2012)
TGR5 potentiates GLP-1 secretion in response to anionic exchange resins
Taoufiq Harach et al.
SCIENTIFIC REPORTS (2012)
Synthetic Farnesoid X Receptor Agonists Induce High-Density Lipoprotein-Mediated Transhepatic Cholesterol Efflux in Mice and Monkeys and Prevent Atherosclerosis in Cholesteryl Ester Transfer Protein Transgenic Low-Density Lipoprotein Receptor (-/-) Mice
Eva Hambruch et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2012)
Carcinogenicity of deoxycholate, a secondary bile acid
Carol Bernstein et al.
ARCHIVES OF TOXICOLOGY (2011)
The nuclear receptor FXR regulates hepatic transport and metabolism of glutamine and glutamate
Barbara Renga et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2011)
Fibroblast Growth Factor 19 Treatment Ameliorates Disruption of Hepatic Lipid Metabolism in Farnesoid X Receptor (Fxr)-Null Mice
Masaaki Miyata et al.
BIOLOGICAL & PHARMACEUTICAL BULLETIN (2011)
Role of farnesoid X receptor (FXR) in the process of differentiation of bone marrow stromal cells into osteoblasts
Hichame Id Boufker et al.
BONE (2011)
FGF15/19 Regulates Hepatic Glucose Metabolism by Inhibiting the CREB-PGC-1α Pathway
Matthew J. Potthoff et al.
CELL METABOLISM (2011)
TGR5 Activation Inhibits Atherosclerosis by Reducing Macrophage Inflammation and Lipid Loading
Thijs W. H. Pols et al.
CELL METABOLISM (2011)
Molecular Control of Systemic Bile Acid Homeostasis by the Liver Glucocorticoid Receptor
Adam J. Rose et al.
CELL METABOLISM (2011)
Farnesoid X Receptor Deficiency Improves Glucose Homeostasis in Mouse Models of Obesity
Janne Prawitt et al.
DIABETES (2011)
Bile Acid Is a Host Factor That Regulates the Composition of the Cecal Microbiota in Rats
K. B. M. Saiful Islam et al.
GASTROENTEROLOGY (2011)
Farnesoid X receptor activation inhibits inflammation and preserves the intestinal barrier in inflammatory bowel disease
Raffaella M. Gadaleta et al.
GUT (2011)
Sterol Transporter Adenosine Triphosphate-Binding Cassette Transporter G8, Gallstones, and Biliary Cancer in 62,000 Individuals from the General Population
Stefan Stender et al.
HEPATOLOGY (2011)
The G-Protein-Coupled Bile Acid Receptor, Gpbar1 (TGR5), Negatively Regulates Hepatic Inflammatory Response Through Antagonizing Nuclear Factor Kappa Light-Chain Enhancer of Activated B Cells (NF-κB) in Mice
Yan-Dong Wang et al.
HEPATOLOGY (2011)
Lowering Bile Acid Pool Size with a Synthetic Farnesoid X Receptor (FXR) Agonist Induces Obesity and Diabetes through Reduced Energy Expenditure
Mitsuhiro Watanabe et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Constitutive androstane receptor activation stimulates faecal bile acid excretion and reverse cholesterol transport in mice
Anne Laure Sberna et al.
JOURNAL OF HEPATOLOGY (2011)
The G Protein-Coupled Bile Acid Receptor, TGR5, Stimulates Gallbladder Filling
Tingting Li et al.
MOLECULAR ENDOCRINOLOGY (2011)
Intestinal homeostasis and its breakdown in inflammatory bowel disease
Kevin J. Maloy et al.
NATURE (2011)
Farnesoid X Receptor (FXR) Activation and FXR Genetic Variation in Inflammatory Bowel Disease
Rian M. Nijmeijer et al.
PLOS ONE (2011)
The Bile Acid Receptor GPBAR-1 (TGR5) Modulates Integrity of Intestinal Barrier and Immune Response to Experimental Colitis
Sabrina Cipriani et al.
PLOS ONE (2011)
Systemic gut microbial modulation of bile acid metabolism in host tissue compartments
Jonathan R. Swann et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2011)
FGF19 as a Postprandial, Insulin-Independent Activator of Hepatic Protein and Glycogen Synthesis
Serkan Kir et al.
SCIENCE (2011)
Dose-Response of Five Bile Acids on Serum and Liver Bile Acid Concentrations and Hepatotoxicty in Mice
Peizhen Song et al.
TOXICOLOGICAL SCIENCES (2011)
Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes
Alexander A. Goldberg et al.
AGING-US (2010)
Liver Regeneration after Partial Hepatectomy Critical Analysis of Mechanistic Dilemmas
George K. Michalopoulos
AMERICAN JOURNAL OF PATHOLOGY (2010)
The normal mechanisms of pregnancy-induced liver growth are not maintained in mice lacking the bile acid sensor Fxr
Alexandra Milona et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2010)
The membrane-bound bile acid receptor TGR5 (Gpbar-1) is localized in the primary cilium of cholangiocytes
Verena Keitel et al.
BIOLOGICAL CHEMISTRY (2010)
The nuclear receptor FXR is expressed in pancreatic β-cells and protects human islets from lipotoxicity
Iuliana Ristea Popescu et al.
FEBS LETTERS (2010)
The Bile Acid Receptor TGR5 (Gpbar-1) Acts as a Neurosteroid Receptor in Brain
Verena Keitel et al.
GLIA (2010)
Farnesold X Receptor Alleviates Age-Related Proliferation Defects in Regenerating Mouse Livers by Activating Forkhead Box m1b Transcription
Wei-Dong Chen et al.
HEPATOLOGY (2010)
Hypertrophic Cardiomyopathy and Dysregulation of Cardiac Energetics in a Mouse Model of Biliary Fibrosis
Moreshwar S. Desai et al.
HEPATOLOGY (2010)
Effects of nuclear receptor FXR on the regulation of liver lipid metabolism in patients with non-alcoholic fatty liver disease
Zhao-Xia Yang et al.
HEPATOLOGY INTERNATIONAL (2010)
Identification of Novel Pathways That Control Farnesoid X Receptor-mediated Hypocholesterolemia
Yanqiao Zhang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
The Farnesoid X Receptor Regulates Adipocyte Differentiation and Function by Promoting Peroxisome Proliferator-activated Receptor-γ and Interfering with the Wnt/β-Catenin Pathways
Mouaadh Abdelkarim et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Bile salts of vertebrates: structural variation and possible evolutionary significance
Alan F. Hofmann et al.
JOURNAL OF LIPID RESEARCH (2010)
FXR activation reverses insulin resistance and lipid abnormalities and protects against liver steatosis in Zucker (fa/fa) obese rats
Sabrina Cipriani et al.
JOURNAL OF LIPID RESEARCH (2010)
Hydrophobic bile salts inhibit gallbladder smooth muscle function via stimulation of GPBAR1 receptors and activation of KATP channels
Brigitte Lavoie et al.
JOURNAL OF PHYSIOLOGY-LONDON (2010)
Functional Characterization of the Semisynthetic Bile Acid Derivative INT-767, a Dual Farnesoid X Receptor and TGR5 Agonist
Giovanni Rizzo et al.
MOLECULAR PHARMACOLOGY (2010)
Missing link identified: GpBAR1 is a neuronal bile acid receptor
S. J. Keely
NEUROGASTROENTEROLOGY AND MOTILITY (2010)
Expression and function of the bile acid receptor GpBAR1 (TGR5) in the murine enteric nervous system
D. P. Poole et al.
NEUROGASTROENTEROLOGY AND MOTILITY (2010)
Gut Microbiota in Health and Disease
Inna Sekirov et al.
PHYSIOLOGICAL REVIEWS (2010)
Bile Acid-Induced Arrhythmia Is Mediated by Muscarinic M2 Receptors in Neonatal Rat Cardiomyocytes
Siti H. Sheikh Abdul Kadir et al.
PLOS ONE (2010)
Mutational Characterization of the Bile Acid Receptor TGR5 in Primary Sclerosing Cholangitis
Johannes R. Hov et al.
PLOS ONE (2010)
Bile acids: short and long term effects in the intestine
Antal Bajor et al.
SCANDINAVIAN JOURNAL OF GASTROENTEROLOGY (2010)
Antiatherosclerotic effect of farnesoid X receptor
Andrea Mencarelli et al.
AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY (2009)
FXR Acetylation Is Normally Dynamically Regulated by p300 and SIRT1 but Constitutively Elevated in Metabolic Disease States
Jongsook Kim Kemper et al.
CELL METABOLISM (2009)
TGR5-Mediated Bile Acid Sensing Controls Glucose Homeostasis
Charles Thomas et al.
CELL METABOLISM (2009)
A New Mechanism for Bile Acid Diarrhea: Defective Feedback Inhibition of Bile Acid Biosynthesis
Julian R. F. Walters et al.
CLINICAL GASTROENTEROLOGY AND HEPATOLOGY (2009)
Bile acid signaling pathways increase stability of Small Heterodimer Partner (SHP) by inhibiting ubiquitin-proteasomal degradation
Ji Miao et al.
GENES & DEVELOPMENT (2009)
Bile Acids Activate Fibroblast Growth Factor 19 Signaling in Human Hepatocytes to Inhibit Cholesterol 7 alpha-Hydroxylase Gene Expression
Kwang-Hoon Song et al.
HEPATOLOGY (2009)
The Membrane-Bound Bile Acid Receptor TGR5 Is Localized in the Epithelium of Human Gallbladders
Verena Keitel et al.
HEPATOLOGY (2009)
Fibroblast Growth Factor-19, a Novel Factor That Inhibits Hepatic Fatty Acid Synthesis
Sushant Bhatnagar et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Physiological concentrations of bile acids down-regulate agonist induced secretion in colonic epithelial cells
Niamh Keating et al.
JOURNAL OF CELLULAR AND MOLECULAR MEDICINE (2009)
Farnesoid X receptor agonist WAY-362450 attenuates liver inflammation and fibrosis in murine model of non-alcoholic steatohepatitis
Songwen Zhang et al.
JOURNAL OF HEPATOLOGY (2009)
The Bile Acid Sensor Farnesoid X Receptor Is a Modulator of Liver Immunity in a Rodent Model of Acute Hepatitis
Andrea Mencarelli et al.
JOURNAL OF IMMUNOLOGY (2009)
The Bile Acid Receptor FXR Is a Modulator of Intestinal Innate Immunity
Piero Vavassori et al.
JOURNAL OF IMMUNOLOGY (2009)
Bile acid transporters
Paul A. Dawson et al.
JOURNAL OF LIPID RESEARCH (2009)
Activation of farnesoid X receptor prevents atherosclerotic lesion formation in LDLR-/- and apoE-/- mice
Helen B. Hartman et al.
JOURNAL OF LIPID RESEARCH (2009)
Discovery of 6α-Ethyl-23(S)-methylcholic Acid (S-EMCA, INT-777) as a Potent and Selective Agonist for the TGR5 Receptor, a Novel Target for Diabesity
Roberto Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Discovery of XL335 (WAY-362450), a Highly Potent, Selective, and Orally Active Agonist of the Farnesoid X Receptor (FXR)
Brenton Flatt et al.
JOURNAL OF MEDICINAL CHEMISTRY (2009)
Farnesoid X Receptor Deficiency Induces Nonalcoholic Steatohepatitis in Low-Density Lipoprotein Receptor-Knockout Mice Fed a High-Fat Diet
Bo Kong et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2009)
Serum Bile Acids Are Higher in Humans With Prior Gastric Bypass: Potential Contribution to Improved Glucose and Lipid Metabolism
Mary-Elizabeth Patti et al.
OBESITY (2009)
Expression and function of the bile acid receptor TGR5 in Kupffer cells
Verena Keitel et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2008)
A translational view on the biliary lipid secretory network
Giuseppe Lo Sasso et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2008)
Bile acids: Chemistry, pathochemistry, biology, pathobiology, and therapeutics
A. F. Hofmann et al.
CELLULAR AND MOLECULAR LIFE SCIENCES (2008)
Activation of the farnesoid X receptor represses PCSK9 expression in human hepatocytes
Cedric Langhi et al.
FEBS LETTERS (2008)
Farnesoid X Receptor Antagonizes Nuclear Factor κB in Hepatic Inflammatory Response
Yan-Dong Wang et al.
HEPATOLOGY (2008)
Novel potent and selective bile acid derivatives as TGR5 agonists: Biological screening, structure-activity relationships, and molecular modeling studies
Hiroyuki Sato et al.
JOURNAL OF MEDICINAL CHEMISTRY (2008)
Lithocholic acid down-regulation of NF-κB activity through vitamin D receptor in colonic cancer cells
Jun Sun et al.
JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY (2008)
Farnesoid X receptor protects liver cells from apoptosis induced by serum deprivation in vitro and fasting in vivo
Yan-Dong Wang et al.
MOLECULAR ENDOCRINOLOGY (2008)
Hepatocyte-specific ablation of Foxa2 alters bile acid homeostasis and results in endoplasmic reticulum stress
Irina M. Bochkis et al.
NATURE MEDICINE (2008)
Targeting bile-acid signalling for metabolic diseases
Charles Thomas et al.
NATURE REVIEWS DRUG DISCOVERY (2008)
Farnesoid X receptor ligands inhibit vascular smooth muscle cell inflammation and migration
Yoyo T. Y. Li et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2007)
Differential regulation of bile acid homeostasis by the farnesoid X receptor in liver and intestine
Insook Kim et al.
JOURNAL OF LIPID RESEARCH (2007)
Anti-hyperglycemic activity of a TGR5 agonist isolated from Olea europaea
Hiroyuki Sato et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2007)
Tissue-specific expression of βKlotho and fibroblast growth factor (FGF) receptor Isoforms determines metabolic activity of FGF19 and FGF21
Hiroshi Kurosu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Liver-specific activities of FGF19 require Klotho beta
Benjamin C. Lin et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
Increased gallstone risk in humans conferred by common variant of hepatic ATP-binding cassette transporter for cholesterol
Frank Grunhage et al.
HEPATOLOGY (2007)
A genome-wide association scan identifies the hepatic cholesterol transporter ABCG8 as a susceptibility factor for human gallstone disease
Stephan Buch et al.
NATURE GENETICS (2007)
Functional variants of the central bile acid sensor FXR identified in intrahepatic cholestasis of pregnancy
Saskia W. C. Van Mil et al.
GASTROENTEROLOGY (2007)
Alterations in xenobiotic metabolism in the long-lived Little mice
Daniel Amador-Noguez et al.
AGING CELL (2007)
Ursodeoxycholic acid improves muscle contractility and inflammation in symptomatic gallbladders with cholesterol gallstones
Michele Pier Luca Guarino et al.
GUT (2007)
Spontaneous hepatocarcinogenesis in farnesoid X receptor-null mice
Insook Kim et al.
CARCINOGENESIS (2007)
A bile acid-like steroid modulates Caenorhabditis elegans lifespan through nuclear receptor signaling
Birgit Gerisch et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2007)
Spontaneous development of liver tumors in the absence of the bile acid receptor farnesoid X receptor
Fan Yang et al.
CANCER RESEARCH (2007)
Nuclear receptors in human immune cells: Expression and correlations
Andrea B. Schote et al.
MOLECULAR IMMUNOLOGY (2007)
Effects of FXR in foam-cell formation and atherosclerosis development
Grace L. Guo et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS (2006)
Identification of a hormonal basis for gallbladder filling
Mihwa Choi et al.
NATURE MEDICINE (2006)
FXR deficiency causes reduced atherosclerosis in Ldlr-/- mice
Yanqiao Zhang et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
Targeted deletion of Gpbar1 protects mice from cholesterol gallstone formation
Galya Vassileva et al.
BIOCHEMICAL JOURNAL (2006)
Primary sclerosing cholangitis: Summary of a workshop
Nicholas F. LaRusso et al.
HEPATOLOGY (2006)
Coordinated induction of bile acid detoxification and alternative elimination in mice:: role of FXR-regulated organic solute transporter-α/β in the adaptive response to bile acids
G Zollner et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Regulation of the mouse organic solute transporter α-β, Ostα-Ostβ, by bile acids
T Frankenberg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
The farnesoid X receptor modulates adiposity and peripheral insulin sensitivity in mice
B Cariou et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2006)
Nuclear receptor-dependent bile acid signaling is required for normal liver regeneration
WD Huang et al.
SCIENCE (2006)
Endocrine functions of bile acids
SM Houten et al.
EMBO JOURNAL (2006)
Farnesoid X receptor is essential for normal glucose homeostasis
K Ma et al.
JOURNAL OF CLINICAL INVESTIGATION (2006)
Identification of ligands for DAF-12 that govern Dauer formation and reproduction in C. elegans
DL Motola et al.
CELL (2006)
Regulation of antibacterial defense in the small intestine by the nuclear bile acid receptor
T Inagaki et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Excellent long-term survival in patients with primary biliary cirrhosis and biochemical response to ursodeoxycholic acid
A Parés et al.
GASTROENTEROLOGY (2006)
The nuclear receptor for bile acids, FXR, transactivates human organic solute transporter-α and -β genes
JF Landrier et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2006)
Mechanism of growth inhibition by free bile acids in lactobacilli and bifidobacteria
P Kurdi et al.
JOURNAL OF BACTERIOLOGY (2006)
A role for FXR and human FGF-19 in the repression of paraoxonase-1 gene expression by bile acids
DM Shih et al.
JOURNAL OF LIPID RESEARCH (2006)
Bile salt biotransformations by human intestinal bacteria
JM Ridlon et al.
JOURNAL OF LIPID RESEARCH (2006)
Bile acids decrease hepatic paraoxonase 1 expression and plasma high-density lipoprotein levels via FXR-mediated signaling of FGFR4
A Gutierrez et al.
ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY (2006)
Bile acids induce energy expenditure by promoting intracellular thyroid hormone activation
M Watanabe et al.
NATURE (2006)
Activation of the nuclear receptor FXR improves hyperglycemia and hyperlipidemia in diabetic mice
YQ Zhang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
FXR regulates organic solute transporters alpha and beta in the adrenal gland, kidney, and intestine
H Lee et al.
JOURNAL OF LIPID RESEARCH (2006)
Loss of functional farnesoid X receptor increases atherosclerotic lesions in apolipoprotein E-deficient mice
EA Hanniman et al.
JOURNAL OF LIPID RESEARCH (2005)
Fibroblast growth factor 15 functions as an enterohepatic signal to regulate bile acid homeostasis
T Inagaki et al.
CELL METABOLISM (2005)
The farnesoid X receptor modulates hepatic carbohydrate metabolism during the fasting-refeeding transition
D Duran-Sandoval et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Transient impairment of the adaptive response to fasting in FXR-deficient mice
B Cariou et al.
FEBS LETTERS (2005)
CAR and PXR agonists stimulate hepatic bile acid and bilirubin detoxification and elimination pathways in mice
M Wagner et al.
HEPATOLOGY (2005)
The methyl transferase PRMT1 functions as co-activator of farnesoid X receptor (FXR)/9-cis retinoid X receptor and regulates transcription of FXR responsive genes
G Rizzo et al.
MOLECULAR PHARMACOLOGY (2005)
Complementary stimulation of hepatobiliary transport and detoxification systems by rifampicin and ursodeoxycholic acid in humans
HU Marschall et al.
GASTROENTEROLOGY (2005)
Impaired negative feedback suppression of bile acid synthesis in mice lacking βKlotho
S Ito et al.
JOURNAL OF CLINICAL INVESTIGATION (2005)
Deoxycholyltaurine-induced vasodilation of rodent aorta is nitric oxide- and muscarinic M3 receptor-dependent
S Khurana et al.
EUROPEAN JOURNAL OF PHARMACOLOGY (2005)
Independent repression of bile acid synthesis and activation of c-Jun N-terminal kinase (JNK) by activated hepatocyte fibroblast growth factor receptor 4 (FGFR4) and bile acids
CD Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Protective effects of 6-ethyl chenodeoxycholic acid, a farnesoid X receptor ligand, in estrogen-induced cholestasis
S Fiorucci et al.
JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS (2005)
Pathophysiology of cholangiopathies
M Strazzabosco et al.
JOURNAL OF CLINICAL GASTROENTEROLOGY (2005)
Bile acids promote glucagon-like peptide-1 secretion through TGR5 in a murine enteroendocrine cell line STC-1
S Katsuma et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2005)
Host-bacterial mutualism in the human intestine
F Bäckhed et al.
SCIENCE (2005)
Expression of ABCG5 and ABCG8 is required for regulation of biliary cholesterol secretion
LQ Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Dual role of orphan nuclear receptor pregnane X receptor in bilirubin detoxification in mice
SPS Saini et al.
HEPATOLOGY (2005)
The interaction between bacteria and bile
M Begley et al.
FEMS MICROBIOLOGY REVIEWS (2005)
Mechanisms of disease: the genetic epidemiology of gallbladder stones
F Lammert et al.
NATURE CLINICAL PRACTICE GASTROENTEROLOGY & HEPATOLOGY (2005)
FXR-activating ligands inhibit rabbit ASBT expression via FXR-SHP-FTF cascade
H Li et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2005)
Expression and activation of the farnesoid X receptor in the vasculature
D Bishop-Bailey et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2004)
Peroxisome proliferator-activated receptor-γ coactivator 1α (PGC-1α) regulates triglyceride metabolism by activation of the nuclear receptor FXR
YQ Zhang et al.
GENES & DEVELOPMENT (2004)
Ligand-dependent activation of the farnesoid X-receptor directs arginine methylation of histone H3 by CARM1
M Ananthanarayanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Prevention of cholesterol gallstone disease by FXR agonists in a mouse model
A Moschetta et al.
NATURE MEDICINE (2004)
Gene expression profile of long-lived Ames dwarf mice and Little mice
D Amador-Noguez et al.
AGING CELL (2004)
Bile acid reduces the secretion of very low density lipoprotein by repressing microsomal triglyceride transfer protein gene expression mediated by hepatocyte nuclear factor-4
H Hirokane et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Fibroblast growth factor 19 increases metabolic rate I and reverses dietary and leptlin-deficient diabetes
L Fu et al.
ENDOCRINOLOGY (2004)
Bile acids regulate gluconeogenic gene expression via small heterodimer partner-mediated repression of hepatocyte nuclear factor 4 and Foxo1
K Yamagata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Complementary roles of farnesoid X receptor, pregnane X receptor, and constitutive androstane receptor in protection against bile acid toxicity
GL Guo et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Resistance of SHP-null mice to bile acid-induced liver damage
L Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
FXR and ABCG5/ABCG8 as determinants of cholesterol gallstone formation from quantitative trait locus mapping in mice
H Wittenburg et al.
GASTROENTEROLOGY (2003)
Farnesoid X receptor agonists suppress hepatic apolipoprotein CIII expression
T Claudel et al.
GASTROENTEROLOGY (2003)
Bile acids activate EGF receptor via a TGF-α-dependent mechanism in human cholangiocyte cell lines
NW Werneburg et al.
AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY (2003)
Definition of a novel growth factor-dependent signal cascade for the suppression of bile acid biosynthesis
JA Holt et al.
GENES & DEVELOPMENT (2003)
Induction of bilirubin clearance by the constitutive androstane receptor (CAR)
WD Huang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2003)
A chemical, genetic, and structural analysis of the nuclear bile acid receptor FXR
M Downes et al.
MOLECULAR CELL (2003)
A G protein-coupled receptor responsive to bile acids
Y Kawamata et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The farnesoid X-receptor is an essential regulator of cholesterol homeostasis
G Lambert et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
Identification of membrane-type receptor for bile acids (M-BAR)
T Maruyama et al.
BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS (2002)
Functional interaction of lithocholic acid conjugates with M3 muscarinic receptors on a human colon cancer cell line
KR Cheng et al.
BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR BASIS OF DISEASE (2002)
The small heterodimer partner interacts with the liver X receptor α and represses its transcriptional activity
C Brendel et al.
MOLECULAR ENDOCRINOLOGY (2002)
6α-ethyl-chenodeoxycholic acid (6-ECDCA), a potent and selective FXR agonist endowed with anticholestatic activity
R Pellicciari et al.
JOURNAL OF MEDICINAL CHEMISTRY (2002)
STAT3 contributes to the mitogenic response of hepatocytes during liver regeneration
W Li et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Loss of nuclear receptor SHP impairs but does not eliminate negative feedback regulation of bile acid synthesis
TA Kerr et al.
DEVELOPMENTAL CELL (2002)
A natural product that lowers cholesterol as an antagonist ligand for FXR
NL Urizar et al.
SCIENCE (2002)
Vitamin D receptor as an intestinal bile acid sensor
M Makishima et al.
SCIENCE (2002)
Lack of intestinal bile results in delayed liver regeneration of normal rat liver after hepatectomy accompanied by impaired cyclin E-associated kinase activity
JJ Ueda et al.
SURGERY (2002)
Regulatory effects of deoxycholic acid, a component of the anti-inflammatory traditional Chinese medicine Niuhuang, on human leukocyte response to chemoattractants
X Chen et al.
BIOCHEMICAL PHARMACOLOGY (2002)
Regulation of multidrug resistance-associated protein 2 (ABCC2) by nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor
HR Kast et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2002)
Methylation at arginine 17 of histone H3 is linked to gene activation
UM Bauer et al.
EMBO REPORTS (2002)
Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump
JRM Plass et al.
HEPATOLOGY (2002)
Human bile salt export pump promoter is transactivated by the farnesoid X receptor/bile acid receptor
M Ananthanarayanan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity
JL Staudinger et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
An essential role for nuclear receptors SXR/PXR in detoxification of cholestatic bile acids
W Xie et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2001)
Characterization of chenodeoxycholic acid as an endogenous antagonist of the G-coupled formyl peptide receptors
X Chen et al.
INFLAMMATION RESEARCH (2000)
Targeted disruption of the nuclear receptor FXR/BAR impairs bile acid and lipid homeostasis
CJ Sinal et al.
CELL (2000)
A regulatory cascade of the nuclear receptors FXR, SHP-1, and LRH-1 represses bile acid biosynthesis
B Goodwin et al.
MOLECULAR CELL (2000)
Identification of a chemical tool for the orphan nuclear receptor FXR
PR Maloney et al.
JOURNAL OF MEDICINAL CHEMISTRY (2000)
Elevated cholesterol metabolism and bile acid synthesis in mice lacking membrane tyrosine kinase receptor FGFR4
CD Yu et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
Chronic cholestatic diseases
R Poupon et al.
JOURNAL OF HEPATOLOGY (2000)
Molecular basis for feedback regulation of bile acid synthesis by nuclear receptors
TT Lu et al.
MOLECULAR CELL (2000)
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