期刊
CLINICAL NUTRITION
卷 35, 期 3, 页码 645-649出版社
CHURCHILL LIVINGSTONE
DOI: 10.1016/j.clnu.2015.04.001
关键词
ATP; Fructose infusion; Oral challenge; NAFLD; Liver; 31P MRS
资金
- BBSRC
- Unilever
- MRC [G0901321, MR/M009122/1] Funding Source: UKRI
- Biotechnology and Biological Sciences Research Council [1068691] Funding Source: researchfish
- Medical Research Council [MR/M009122/1, G0901321] Funding Source: researchfish
Background: Impaired homeostasis of hepatic ATP has been associated with NAFLD. An intravenous fructose infusion has been shown to be an effective challenge to monitor the depletion and subsequent recovery of hepatic ATP reserves using P-31 MRS. Aims: The purpose of this study was to evaluate the effects of an oral rather than intravenous fructose challenge on hepatic ATP reserves in healthy subjects. Methods: Self-reported healthy males were recruited. Following an overnight fast, baseline liver glycogen and lipid levels were measured using Magnetic Resonance Spectroscopy (MRS). Immediately after consuming a 500 ml 75 g fructose drink (1275 kJ) subjects were scanned continuously for 90 min to acquire dynamic P-31 MRS measurements of liver ATP reserves. Results: A significant effect on ATP reserves was observed across the time course (P < 0.05). Mean ATP levels reached a minimum at 50 min which was markedly lower than baseline (80 +/- 17% baseline, P < 0.05). Subsequently, mean values tended to rise but did not reach statistical significance above minimum. The time to minimum ATP levels across subjects was negatively correlated with BMI (R-2 = 0.74, P < 0.005). Rates of ATP recovery were not significantly correlated with BMI or liver fat levels, but were negatively correlated with baseline glycogen levels (R-2 = 0.7, P < 0.05). Conclusions: Depletion of ATP reserves can be measured non-invasively following an oral fructose challenge using P-31 MRS. BMI is the best predictor of postprandial ATP homeostasis following fructose consumption. (C) 2015 Elsevier Ltd and European Society for Clinical Nutrition and Metabolism. All rights reserved.
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