期刊
PAIN
卷 162, 期 1, 页码 161-175出版社
LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/j.pain.0000000000002012
关键词
nociception; anterolateral; spinofugal; spinoparabrachial; spinothalamic; commissural; Hoxb8; DCC; Netrin-1; lamina I; projection neurons
资金
- Canadian Institutes of Health Research [PJT-153053, PJT-159839, PJT-162225]
- Brain Canada
- Canadian Foundation for Innovation
- W. Garfield Weston Foundation
Anterolateral system (AS) neurons relay nociceptive information from the spinal cord to the brain through canonical pathways, with disruption of this pathway leading to altered laterality of spinofugal projections and potential impacts on pain localization precision.
Anterolateral system (AS) neurons relay nociceptive information from the spinal cord to the brain, protecting the body from harm by evoking a variety of behaviours and autonomic responses. The developmental programs that guide the connectivity of AS neurons remain poorly understood. Spinofugal axons cross the spinal midline in response to Netrin-1 signalling through its receptor deleted in colorectal carcinoma (DCC); however, the relevance of this canonical pathway to AS neuron development has only been demonstrated recently. Here, we disrupted Netrin-1:DCC signalling developmentally in AS neurons and assessed the consequences on the path finding of the different classes of spinofugal neurons. Many lamina I AS neurons normally innervate the lateral parabrachial nucleus and periaqueductal gray on the contralateral side. The loss of DCC in the developing spinal cord resulted in increased frequency of ipsilateral projection of spinoparabrachial and spinoperiaqueductal gray neurons. Given that contralateral spinofugal projections are largely associated with somatotopic representation of the body, changes in the laterality of AS spinofugal projections may contribute to reduced precision in pain localization observed in mice and humans carrying Dcc mutations.
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