4.6 Article

Acute orofacial pain leads to prolonged changes in behavioral and affective pain components

期刊

PAIN
卷 161, 期 12, 页码 2830-2840

出版社

LIPPINCOTT WILLIAMS & WILKINS
DOI: 10.1097/j.pain.0000000000001970

关键词

Trigeminal pain; Ultrasonic vocalization; Anxiety; Orofacial formalin; Ongoing pain; Postoperative pain

资金

  1. Coordenacao de Aperfeicoamento de Pessoal de Nivel Superior-Brazil (CAPES) [001]
  2. CAPES
  3. National Council for Scientific and Technological Development (CNPq)
  4. CNPq
  5. German Academic Exchange Service (DAAD)
  6. DFG [FOR 2107]
  7. Canadian Institutes of Health Research
  8. Canada-Israel Health Research Initiative - CIHR
  9. Israel Science Foundation
  10. International Development Research Centre
  11. Azrieli Foundation
  12. Canada Research Chair

向作者/读者索取更多资源

Acute pain that persists for a few days is associated with a reduction in patients' quality of life. Orofacial persistent pain promotes psychological disorders such as anxiety, impairs daily essential activities such as eating, and results in decreased social interaction. Here, we investigated whether rats subjected to orofacial formalin injection or intraoral incision surgery display persistent facial heat hyperalgesia, ongoing pain, anxiety-like behavior, and changes in ultrasonic vocalization. Orofacial formalin injection or intraoral incision caused facial heat hyperalgesia for 3 days compared with saline-injected and sham animals. In addition, both experimental groups showed a reduction in the number of entries and in the time spent in the open arms in the elevated plus maze test on day 3, suggesting that anxiety-like behavior developed as a consequence of persistent pain. At this time point, both groups also displayed a reduction in the number of 50-kHz calls, specifically in the flat subtype, which suggests a decrease in social communication. Moreover, on day 3 after surgery, systemic morphine produced robust conditioned place preference in rats subjected to intraoral incision compared with sham, and the former group also presented increased spontaneous facial grooming, revealing the presence of ongoing pain. Finally, Western blot and immunohistochemistry analysis showed a reduction in tyrosine hydroxylase expression in the nucleus accumbens, which may reflect a decrease in mesolimbic dopaminergic activity. Altogether, the results demonstrate that acute orofacial pain causes prolonged changes in behavioral and affective pain components, which may be related to dopaminergic changes in the nucleus accumbens.

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