期刊
ORGANIC PROCESS RESEARCH & DEVELOPMENT
卷 24, 期 8, 页码 1543-1548出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.oprd.0c00303
关键词
chemistry in water; surfactant; amide coupling; scale up; environment sustainability
资金
- Novartis, Inc.
The technology of surfactant chemistry is employed for amide bond construction via the reaction of acyl chlorides with amines in 2 wt % TPGS-750-M aqueous solution. Specifically, this highly efficient method enables a chromatography-free scalable process and recycling of the TPGS-750-M solution.
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