期刊
ORGANIC LETTERS
卷 22, 期 16, 页码 6399-6403出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c02208
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资金
- Natural Sciences and Engineering Research Council of Canada
- Canada Foundation for Innovation
- Innovation PEI
- Nautilus Biosciences CRODA
- Jeanne and Jean-Louis Le'vesque Foundation
A meroterpenoid, guanahanolide A (1), was purified from a fermentation extract of Streptomyces sp. RKBH-B7. The planar structure of guanahanolide A (1) was elucidated by NMR spectroscopy, revealing a meroterpenoid comprised of an unprecedented sesterterpene skeleton. Upon determination of the relative configuration of 1 through X-ray crystallography, its absolute configuration was unambiguously assigned using Mosher ester analysis. Guanahanolide A (1) showed moderate cytotoxicity against human cancer cell lines MCF-7, HTB-26, and HCT-116.
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