期刊
ORGANIC LETTERS
卷 22, 期 13, 页码 5157-5162出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01759
关键词
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资金
- Sanofi
- CNRS
- Chevreul Institute [FR 2638]
- Ministere de l'Enseignement Superieur et de la Recherche, Region Nord - Pas de Calais
- FEDER
Piperazines are privileged scaffolds in medicinal chemistry. Disclosed herein is a visible-light-promoted decarboxylative annulation protocol between a glycine-based diamine and various aldehydes to access 2-aryl, 2-heteroaryl, as well as 2-alkyl piperazines. The iridium-based complex [Ir(ppy)(2)(dtbpy)]PF6 and carbazolyl dicyanobenzene 4CzIPN were found to be the photocatalysts of choice to efficiently perform the transformation under mild conditions, whether in batch or in continuous mode.
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