期刊
ORGANIC LETTERS
卷 22, 期 14, 页码 5407-5411出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01756
关键词
-
资金
- Science and Engineering Research Board (SERB), Government of India [EMR/2016/007021]
The NHC-catalyzed desymmetrization of cyclic-1,3-diketones allowing the enantioselective construction of tricyclic beta-lactones with five contiguous stereocenters, including two quaternary stereocenters, has been developed. The mild and operationally simple addition of a-bromoenals to cyclopentane-1,3-diketone derivatives proceeds via the initial formation of chiral alpha,beta-unsaturated acylazolium intermediates and culminates in a cascade reaction, following the Michael-aldol-Iactonization pathway to deliver the beta-lactone derivatives in moderate to good yields and excellent selectivity.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据