期刊
ORGANIC LETTERS
卷 22, 期 14, 页码 5358-5362出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01249
关键词
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资金
- National Research Foundation of Korea Grant - Korean Government (Ministry of Science and ICT) [2018R1A4A1021703, 2019R1A2B5B03069338]
- Collaborative Genome Program of the Korea Institute of Marine Science and Technology Promotion (KIMST) - Ministry of Oceans and Fisheries (MOF) [20180430]
- Korea Institute of Marine Science & Technology Promotion (KIMST) [2018043010] Funding Source: Korea Institute of Science & Technology Information (KISTI), National Science & Technology Information Service (NTIS)
Pulvomycins B-D (1-3) were discovered from an estuarine Streptomyces strain along with the known pulvomycin (4). The 22-membered macrocyclic lactone structures of 1-3 were determined based on the interpretation of NMR, UV, and MS data, the modified Mosher's method, and Kishi's bidentate chiral solvent NMR spectroscopy. Genomic analysis of the bacterial strain revealed the biosynthetic gene cluster of pulvomycin and enabled us to propose the trans-acyltransferase polyketide biosynthetic pathway. Pulvomycin D displayed potent cytotoxic activity against various cancer cell lines.
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