期刊
ORGANIC LETTERS
卷 22, 期 12, 页码 4852-4857出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01687
关键词
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资金
- National Natural Science Foundation of China [21525207, 21772147]
- Wuhan Morning Light Plan of Youth Science and Technology [2017050300307]
- Fundamental Research Funds for Central Universities [2042018kf0202]
- Program of Introducing Talents of Discipline to Universities of China (111 Project)
A stereodivergent preparation of a-quaternary serine/cysteine derivatives incorporating two adjacent stereogenic centers has been developed through Cu/Ir-catalyzed asymmetric allylation of 2-oxazoline-4-carboxylates and 2-thiazoline-4-carboxylates. Tuning the electronic effect is the key to enhancing the reactivity of 2-oxazoline-4-carboxylates and suppressing the undesired beta-elimination. The salient feature of this protocol is that all four stereoisomers of alpha-quaternary serine and cysteine derivatives could be achieved from the identical starting materials through pairwise combination of two distinct chiral catalysts.
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