期刊
ORGANIC LETTERS
卷 22, 期 12, 页码 4732-4736出版社
AMER CHEMICAL SOC
DOI: 10.1021/acs.orglett.0c01534
关键词
-
资金
- NSFC [21931006, 21921002]
- Sichuan Science and Technology Program [19YYJC2413]
An asymmetric alpha-regioselective allenylation reaction of activated ketimines with 3-butynoates is disclosed under Cu(I) catalysis, probably via the generation of nucleophilic gamma-allenylcopper species in the presence of diisopropylethylamine. A broad range of imines, derived from diverse ketones such as isatins, pyrazolediones, isoquinoline-1,3,4-triones, and even trifluoromethyl alkynyl ketones, can be utilized, generally affording the corresponding alpha-allenyl amine derivatives in high yields (<= 97%) with excellent enantioselectivities (<= 99% ee).
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