期刊
ORAL DISEASES
卷 27, 期 1, 页码 73-93出版社
WILEY
DOI: 10.1111/odi.13502
关键词
head and neck cancer; INHANCE; laryngeal cancer; oral cavity cancer; pooled analysis; prognostic factors; risk factors
资金
- National Institutes of Health (NIH) [P01CA068384, K07CA104231, R01CA048996, R01DE012609, TW001500, R01CA061188, R01DE013158, P50CA090388, R01DA011386, R03CA077954, T32CA009142, U01CA096134, R21ES011667, R01CA078609, R01CA100679, R01CA051845, R01CA030022, DE016631]
- National Cancer Institute (NCI) [R03CA113157, R01-CA90731]
- National Institute of Dental and Craniofacial Research (NIDCR) [R03DE016611, R01DE011979, R01DE013110]
- Italian Association for Research on Cancer (AIRC) [10068]
- Italian League against Cancer
- Italian Ministry of Research
- European Commission [IC18-CT97-0222, IC15-CT98-0332]
- Veterans Affairs Merit Review Funds
- National Institute of Environmental Health Sciences (NIEHS) [P30ES010126]
- Fondo para la Investigacion Cientifica y Tecnologica Argentina (FONCYT)
- Institut Hospital del Mar d'Investigacions Mediques (IMIM)
- Fundacao de Amparo a Pesquisa no Estado de Sao Paulo (FAPESP) [01/01768-2, 04/12054-9, 10/51168-0]
- Fondo de Investigaciones Sanitarias (FIS) of the Spanish Government [FIS 97/0024, FIS 97/0662, BAE 01/5013]
- International Union Against Cancer (UICC)
- Yamagiwa-Yoshida Memorial International Cancer Study Grant
- European Community [QLK1-CT-2001-00182]
- Ministry of Education, Science, Sports, Culture and Technology of Japan [17015052]
- Ministry of Health, Labor and Welfare of Japan [H20-002]
- Italian Foundation for Cancer Research (FIRC)
- Italian Ministry of Education [X8YCBN]
- Fribourg League against Cancer [FOR381.88]
- Swiss Cancer Research [AKT 617]
- Gustave-Roussy Institute [88D28]
- French National Research Agency (ANR)
- French National Cancer Institute (INCA)
- French Agency for Food, Environmental and Occupational Health and Safety (ANSES)
- Fondation pour la Recherche Medicale (FRM)
- Fondation de France [01GB9702/3]
- Fondation ARC pour la Recherche sur le Cancer
- French Ministry of Health
- World Cancer Research Fund
- Ministry of Science, Research and Arts Baden-Wurttemberg
- German Ministry of Education and Research
- Intramural Research Program
- Swiss Research against cancer/Oncosuisse [KFS-700, OCS-1633, KFS1096-09-2000]
- Alper Research Program for Environmental Genomics of the UCLA Jonsson Comprehensive Cancer Center
- French Institute for Public Health Surveillance (InVS)
- French Ministry of Labour
- Johns Hopkins Richard Gelb Cancer Prevention Award
- Universita degli Studi di Milano: Young Investigator Grant Program 2017
- Fundacao de Amparo a Pesquisa do Estado de Sao Paulo (FAPESP) [04/12054-9] Funding Source: FAPESP
The INHANCE consortium's research findings have revealed the association of head and neck cancer with smoking, alcohol consumption, and occupational exposure, as well as the benefits of good oral health, hormonal factors, and fruit and vegetable consumption in reducing the incidence of head and neck cancer. The studies also provide insights into the survival rates and recurrence rates of head and neck cancer.
Objective: To summarize the latest evidence on head and neck cancer epidemiology from the International Head and Neck Cancer Epidemiology (INHANCE) consortium. Subjects and Methods: INHANCE was established in 2004 to elucidate the etiology of head and neck cancer through pooled analyses of individual-level data on a large scale. We summarize results from recent INHANCE-based publications updating our 2015 overview. Results: Seventeen papers were published between 2015 and May 2020. These studies further define the nature of risks associated with tobacco and alcohol, and occupational exposures on head and neck cancer. The beneficial effects on incidence of head and neck cancer were identified for good oral health, endogenous and exogenous hormonal factors, and selected aspects of diet related to fruit and vegetables. INHANCE has begun to develop risk prediction models and to pool follow-up data on their studies, finding that similar to 30% of cases had cancer recurrence and 9% second primary cancers, with overall- and disease-specific 5-year-survival of 51% and 57%, respectively. Conclusions: The number and importance of INHANCE scientific findings provides further evidence of the advantages of large-scale internationally collaborative projects and will support the development of prevention strategies.
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