Optoretinogram: optical measurement of human cone and rod photoreceptor responses to light

Noninvasive, objective measurement of rod function is as significant as that of cone function, and for retinal diseases such as retinitis pigmentosa and age-related macular degeneration, rod function may be a more sensitive biomarker of disease progression and efficacy of treatment than cone function. Functional imaging of single human rod photoreceptors, however, has proven difficult because their small size and rapid functional response pose challenges for the resolution and speed of the imaging system. Here, we describe light-evoked, functional responses of human rods and cones, measured noninvasively using a synchronized. adaptive optics optical coherence tomography (OCT) and. scann ing light ophthalmoscopy (SW) system. The higher lateral resolution of the SW images made it possible to confirm the identity of rods in the corresponding OCT volumes. (C) 2020 Optical Society of America