期刊
NUTRITION
卷 81, 期 -, 页码 -出版社
ELSEVIER SCIENCE INC
DOI: 10.1016/j.nut.2020.110951
关键词
Fatty acids; ABCA1; Epidemiology; DNA methylation; oi-3 PUFA; Epigenetics
资金
- Japan Society for the Promotion of Science [26293144, 17K09139]
- Suzuken Memorial Foundation [18-031]
- Fujita Health University
- Grants-in-Aid for Scientific Research [26293144, 17K09139] Funding Source: KAKEN
A diet rich in fish and ω-3 PUFAs is associated with lower levels of ABCA1 DNA methylation in a Japanese population, potentially revealing the biological mechanisms underlying the protective effects of dietary fish and ω-3 PUFA intakes on cardiovascular disease.
Objectives: A diet rich in fish and oi-3 polyunsaturated fatty acids (PUFAs) has been thought to reduce the risk for cardiovascular disease (CVD). The beneficial effects of fish oil and oi-3 PUFA on CVD can be mediated by epigenetic status of the genes associated with lipid metabolism and inflammation. The aim of this study was to investigate whether dietary fish and fatty acid (FA) intakes are associated with leukocyte ATP-binding cassette transporter A1 (ABCA1) DNA methylation levels in a Japanese population. Methods: This cross-sectional study included 298 adults (137 men and 161 women) without clinical history of CVD or cancer. The pyrosequencing method was used to measure leukocyte ABCA1 DNA methylation levels. Dietary fish and FA intakes were assessed based on the validated food frequency questionnaire. Results: Mean ABCA1 DNA methylation levels were significantly lower in the highest fish intake groups ( 5-6/wk) compared with the lowest intake group (<1-2/wk; P = 0.004). In multivariable linear regression analyses, higher dietary intake of oi-3 PUFAs and oi-3 highly unsaturated fatty acids was significantly associated with decreased levels of ABCA1 DNA methylation (P = 0.001 and 0.005); whereas no significant associations were seen between intake of dietary saturated fatty acid, monounsaturated fatty acid, and oi-6 PUFAs and ABCA1 DNA methylation. Conclusion: Higher dietary fish and oi-3 PUFA intake were associated with lower ABCA1 DNA levels in a Japanese population. The present results may bring potential insights on biological mechanisms underlying the protective effects of dietary fish and oi-3 PUFA intakes on CVD. (c) 2020 Elsevier Inc. All rights reserved.
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