期刊
NEUROTOXICITY RESEARCH
卷 38, 期 4, 页码 833-849出版社
SPRINGER
DOI: 10.1007/s12640-020-00232-x
关键词
Presenilin; PSEN; Alzheimer's disease; gamma-Secretase; Amyloid beta
资金
- Deanship of Scientific Research at Princess Nourah bint Abdulrahman University, through the Fast-track Research Funding Program
Alzheimer's disease (AD) is the most common cause of dementia. Mutations of presenilin (PSEN) genes that encode presenilin proteins have been found as the vital causal factors for early-onset familial AD (FAD). AD pathological features such as memory loss, synaptic dysfunction, and formation of plaques have been successfully mimicked in the transgenic mouse models that coexpress FAD-related presenilin and amyloid precursor protein (APP) variants. gamma-Secretase (GS) is an enzyme that plays roles in catalyzing intramembranous APP proteolysis to release pathogenic amyloid beta (A beta). It has been found that presenilins can play a role as the GS's catalytic subunit. FAD-related mutations in presenilins can modify the site of GS cleavage in a way that can elevate the production of longer and highly fibrillogenic A beta. Presenilins can interact with beta-catenin to generate presenilin complexes. Aforesaid interactions have also been studied to observe the mutational and physiological activities in the catenin signal transduction pathway. Along with APP, GS can catalyze intramembrane proteolysis of various substrates that play a vital role in synaptic function.PSENmutations can cause FAD with autosomal dominant inheritance and early onset of the disease. In this article, we have reviewed the current progress in the analysis ofPSENsand the correlation ofPSENmutations and AD pathogenesis.
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