期刊
CLINICAL NEUROPHYSIOLOGY
卷 127, 期 2, 页码 1445-1451出版社
ELSEVIER IRELAND LTD
DOI: 10.1016/j.clinph.2015.10.042
关键词
Sleep; Vegetative state; Minimally conscious state; Coma; EEG
Objective: This study aimed to evaluate, through polysomnographic analysis, the prognostic value of sleep patterns, compared to other prognostic factors, in patients with disorders of consciousness (DOCs) in the sub-acute phase. Methods: Twenty-seven patients underwent 24-h polysomnography and clinical evaluation 3.5 +/- 2 months after brain injury. Their clinical outcome was assessed 18.5 +/- 9.9 months later. Polysomnographic recordings were evaluated using visual and quantitative indexes. A general linear model was applied to identify features able to predict clinical outcome. Clinical status at follow-up was analysed as a function of the baseline clinical status, the interval between brain injury and followup evaluation, patient age and gender, the aetiology of the injury, the lesion site, and visual and quantitative sleep indexes. Results: A better clinical outcome was predicted by a visual index indicating the presence of sleep integrity (p = 0.0006), a better baseline clinical status (p = 0.014), and younger age (p = 0.031). Addition of the quantitative sleep index strengthened the prediction. Conclusions: More structured sleep emerged as a valuable predictor of a positive clinical outcome in subacute DOC patients, even stronger than established predictors (e. g. age and baseline clinical condition). Significance: Both visual and quantitative sleep evaluation could be helpful in predicting clinical outcome in sub-acute DOCs. (C) 2015 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.
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