期刊
NEURON
卷 107, 期 3, 页码 552-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.05.008
关键词
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资金
- World Premier International Research Center Initiative from MEXT, JST CREST [JPMJCR1655]
- JSPS KAKENHI [25000015, 18H04012, 16K18359, 15F15408, 26115502, 25116530, JP16H06280, 19F19310, 20H03552]
- Takeda Science Foundation
- Shimadzu Science Foundation
- Kanae Foundation
- Research Foundation for Opto-Science and Technology
- Ichiro Kanehara Foundation
- Kato Memorial Bioscience Foundation
- Japan Foundation for Applied Enzymology
- SENSHIN Medical Research Foundation
- Life Science Foundation of Japan
- Uehara Memorial Foundation
- Brain Science Foundation
- Kowa Life Science Foundation
- Inamori Research Grants Program
- GSK Japan
- Tokyo Biochemical Research Foundation
- JSPS FPD
- BBSRC [BB/M025128/1] Funding Source: UKRI
- Grants-in-Aid for Scientific Research [18H04012, 20H03552, 19F19310] Funding Source: KAKEN
The occurrence of dreaming during rapid eye movement (REM) sleep prompts interest in the role of REM sleep in hippocampal-dependent episodic memory. Within the mammalian hippocampus, the dentate gyrus (DG) has the unique characteristic of exhibiting neurogenesis persisting into adulthood. Despite their small numbers and sparse activity, adult-born neurons (ABNs) in the DG play critical roles in memory; however, their memory function during sleep is unknown. Here, we investigate whether young ABN activity contributes to memory consolidation during sleep using Ca2+ imaging in freely moving mice. We found that contextual fear learning recruits a population of young ABNs that are reactivated during subsequent REM sleep against a backdrop of overall reduced ABN activity. Optogenetic silencing of this sparse ABN activity during REM sleep alters the structural remodeling of spines on ABN dendrites and impairs memory consolidation. These findings provide a causal link between ABN activity during REM sleep and memory consolidation.
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