期刊
NEURON
卷 107, 期 5, 页码 805-820出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.07.011
关键词
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资金
- Harvard Brain Science Initiative
- MEXT [17H05591, 17H05986, 19H05233, 19K16305, 19J00974, 19H05646]
- Nakajima Foundation
- NIH Biobehavioral Research Awards for Innovative New Scientists (BRAINS) [1-R01MH104175]
- NIH [1R01MH111729-01]
- James and Audrey Foster MGH Research Scholar Award
- Ellison Medical Foundation New Scholar in Aging
- Whitehall Foundation
- Inscopix Decode Award
- NARSAD Independent Investigator Award
- Ellison Family Philanthropic
- Blue Guitar Fund
- Harvard Neurodiscovery Center/MADRC Center pilot grant award
- Alzheimer's Association
- Harvard Stem Cell Institute (HSCI) development grant
- HSCI seed grant
- RIKEN Center for Brain Science
- NIH-NIA [1R01AG048908-01A1]
- Grants-in-Aid for Scientific Research [17H05591, 17H05986, 19K16305, 19H05233, 19H05646, 19J00974] Funding Source: KAKEN
The hippocampus and its extended network contribute to encoding and recall of episodic experiences. Drawing from recent anatomical, physiological, and behavioral studies, we propose that hippocampal engrams function as indices to mediate memory recall. We broaden this idea to discuss potential relationships between engrams and hippocampal place cells, as well as the molecular, cellular, physiological, and circuit determinants of engrams that permit flexible routing of information to intraand extrahippocampal circuits for reinstatement, a feature critical to memory indexing. Incorporating indexing into frameworks of memory function opens new avenues of study and even therapies for hippocampal dysfunction.
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