期刊
NEURON
卷 107, 期 5, 页码 972-+出版社
CELL PRESS
DOI: 10.1016/j.neuron.2020.06.012
关键词
-
资金
- Defense Advanced Research Projects Agency (DARPA) [W911NF-14-2-0043]
- Simons Collaboration on the Global Brain
- National Institutes of Health (NIH) BRAIN grant [R01-NS104923]
Neural decoding and neuromodulation technologies hold great promise for treating mood and other brain disorders in next-generation therapies that manipulate functional brain networks. Here we perform a novel causal network analysis to decode multiregional communication in the primate mood processing network and determine how neuromodulation, short-burst tetanic microstimulation (sbTetMS), alters multiregional network communication. The causal network analysis revealed a mechanism of network excitability that regulates when a sender stimulation site communicates with receiver sites. Decoding network excitability from neural activity at modulator sites predicted sender-receiver communication, whereas sbTetMS neuromodulation temporarily disrupted sender-receiver communication. These results reveal specific network mechanisms of multiregional communication and suggest a new generation of brain therapies that combine neural decoding to predict multiregional communication with neuromodulation to disrupt multiregional communication.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据